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TranscriptomicsControl of Virulence Gene Expression in Citrobacter rodentium by Trascription Factor RegA
Identification of the targets of RegA with and without bicarbonate stimulation by comparing RegA knockout to multicopy RegA transgenics. RegA is an AraC like transcription factor identified in a mutational screen for virulence genes in Citrobacter rodentium, an attaching and effacing pathogen that ...
ORGANISM(S): Citrobacter rodentium 
2010-05-19 | E-GEOD-12876 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile in the colon in response to C. rodentium infection.
The identification of Atg16L1 as a susceptibility gene has implicated antibacterial autophagy in the pathogenesis of Crohn's disease, a major type of inflammatory bowel disease (IBD). However, the role of Atg16L1 during extracellular bacterial infections of the intestine has not been sufficiently ex...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-49109 | biostudies-arrayexpress
TranscriptomicsAnalysis of the evolutionary adaptation of an AraC-like global regulatory protein in the murine enteric pathogen Citrobacter rodentium
An experiment to test the equivalence of the Citrobacter rodentium RegA and E.Coli SMS 3-5 homologue 8 Conditions (4 Genotypes by 2 treatments) in duplicate. Reference design without dye swaps.
ORGANISM(S): Citrobacter rodentium 
2015-02-19 | E-GEOD-57689 | biostudies-arrayexpress
ProteomicsC. rodentium remodels metabolism in IEC
The mechanisms by which the mouse pathogen Citrobacter rodentium triggers effacement of the brush border microvilli, colitis, hyperplasia and dysbiosis remain poorly understood. We investigated the impact of C. rodentium infection on the proteomic and metabolic landscapes of intestinal epithelial ce...
ORGANISM(S): Citrobacter rodentium Mus musculus (Mouse) 
2018-01-10 | PXD005004 | Pride
Colon Lc-msms Citrobacter rodentium Mouse Tmt Phosphorylation 
TranscriptomicsOpioid exacerbates gut dysbiosis in a murine model Citrobacter rodentium infection
Opioids analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit their use. It has been recently demonstrated that morphine treatment results in significant disruption in gut barrie...
ORGANISM(S): Mus musculus 
2020-02-18 | E-MTAB-7503 | biostudies-arrayexpress
ProteomicsCitrobacter rodentium ICC168 CPX SILAC
SILAC experiment to investigate proteome changes in response to the disruption of CPX in Citrobacter rodentium ICC168.
ORGANISM(S): Citrobacter rodentium ICC168 
2019-01-07 | PXD009049 | Pride
Lc-ms Bacterial Silac 
ProteomicsCitrobacter rodentium triggers exaggerated mucosal responses in mice developing severe intestinal disease
Citrobacter rodentium is commonly used to elucidate mucosal responses to infection in mice developing mild disease (e.g. C57BL/6), while little is known about host responses to infection in mice developing severe disease (e.g. C3H/HeN). We report that the phyla Bacteroidetes is a minor component of ...
ORGANISM(S): Citrobacter rodentium Mus musculus (Mouse) 
2020-01-21 | PXD012846 | Pride
Colon Citrobacter Mouse Tmt Lc-ms/ms 
TranscriptomicsGene expression in IL-10-deficient and wild-type mice following Citrobacter rodentium infection
To further understand immune mechanims involved in regulating intestinal inflammation, we employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential of regulating inflammation in the absence of IL-10. Whole colon tissue from IL-10-deficient and...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55812 | biostudies-arrayexpress
TranscriptomicsBulk RNA-Sequencing of brain hemispheres of mice with colitis caused by Citrobacter rodentium infection
Whole right brain hemispheres of mice with Citrobacter rodentium infection-induced colitis and controls to study the impact of gut inflammation on the brain
ORGANISM(S): Mus musculus 
2026-01-01 | E-MTAB-15484 | biostudies-arrayexpress
ProteomicsIntestinal crypt cells and the microbiome undergo abrupt reprogramming at the onset of colonic infection
We used the mouse pathogen Citrobacter rodentium to model gut infections. Following oral inoculation C. rodentium resides in the caecum for the first 3 days, before it infects the colon on the 4th day. Here we show that while the host is unresponsive to the infection on day 3, there is an abrupt rep...
ORGANISM(S): Citrobacter rodentium Mus musculus (Mouse) 
2019-03-05 | PXD012031 | Pride
Colon Infection Mouse Citrobacter Tmt 
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