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ProteomicsTropism of SARS-CoV-2 in commonly used laboratory cell-lines and their proteomic landscape during infection
The present pandemic by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is driving increased research activities in order to understand the basic biology of the virus and determining effective therapeutic strategies. The commonly used laboratory cell-lines of human origin are the first ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD023760 | Pride
Type-i intereferon Sars-cov-2 Proteomics Tmprss2 Cellular tropism Ace-2 Cytopathogenicity Cell-lines 
ProteomicsPeripheral blood CD4+CCR6+ compartment differentiate HIV-1 positive elite controllers from long-term successfully treated individuals
Antiretroviral therapy (ART) has the potency of suppressing systemic viral replication and spread. Still, persistent human immunodeficiency virus type-1 (HIV) survive for decades during treatment in latently infected cells, making up the latent viral reservoir. This reservoir is believed to reside i...
ORGANISM(S): Homo sapiens (Human) 
2022-04-22 | PXD027749 | Pride
Hiv Cd4+ccr6+- Peripheral blood 
ProteomicsMetabolic reprogramming and host-immune response against Crimean-Congo Hemorrhagic Fever Viruses (CCHFV) during acute infection
The pathogenesis and host viral interactions of the Crimean–Congo hemorrhagic fever virus (CCHFV) are convoluted and have not been evaluated previously. To understand the host immune responses against CCHFV, we have performed a global transcriptomic analysis of peripheral blood mononuclear cells fro...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD022672 | Pride
Cchfv Cell lines Transcriptomics Lc-ms/ms 
ProteomicsUsing Quantitative Proteomic Assessments and their Association with Long Term Healing Outcomes
Healing after Achilles tendon rupture (ATR) is protracted with high individual variation and unsatisfactory outcome. Biomarkers prognostic of healing are unknown while physical and mechanical factors are used for predicting long-term healing outcomes in clinics today. The present study was designed ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD029202 | Pride
Outcome Proteomics Mass spectrometry Healing Achilles tendon rupture Biomarkers 
ProteomicsLoss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation
The fast skeletal muscle protein α-actinin-3 is absent in 1.5 billion people worldwide due to homozygosity for a nonsense polymorphism in the ACTN3 gene (R577X). The prevalence of the 577X allele increased as modern humans moved to colder climates, suggesting a link between α-actinin-3 deficiency an...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD022997 | Pride
Α-actinin Evolution Muscle 
ProteomicsTrans cohorts metabolic reprograming towards glutaminolysis in long-term successfully treated HIV-Infection: potential role in accelerated aging and latency reversal
Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the pla...
ORGANISM(S): Homo sapiens (Human) 
2021-11-24 | PXD028531 | Pride
Latency Hiv-infection Antiretroviral therapy Glutaminolysis Aging 
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