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This model represents a set of generic, commonly expressed receptor signaling pathways, including EGFR, G-protein-coupled receptor (alpha i, alpha q, alpha 12/13, and alpha s ligands), integrin, and stress pathways.
This is a comprehensive, multi-scale model of ErbB receptor signal transduction in human mammary epithelial cells. This model, constructed manually from published biochemical literature, consists of 245 nodes representing proteins and their post-translational modifications sites, and over 1,000 bioc...
The model includes 38 components and 96 biochemical interactions that regulate the differentiation process of major T cell subtypes, i.e., Th1, Th2, Th17 and iTreg cells. Individual components of the model represent lineage-specifying transcription factors (Tbet, GATA3, RORt, and Foxp3), STAT protei...
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