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TranscriptomicsMitochondrial two-component signaling systems in Candida albicans
Two-component signal transduction pathways are one of the primary means by which microorganisms respond to environmental signals. These signaling cascades originated in prokaryotes and were inherited by eukaryotes via endosymbiotic lateral gene transfer from ancestral cyanobacteria. We report here t...
ORGANISM(S): Candida albicans 
2013-07-02 | E-GEOD-45438 | biostudies-arrayexpress
TranscriptomicsResponse of Saccharomyces cerevisiae (Dal80M-NM-^T) to linoleic acid hydroperoxide
Oxidative stress is experienced by all aerobic organisms and results in cellular damage. The damage caused during oxidative stress is particular to the oxidant challenge faced, and so too is the induced stress response. The eukaryote Saccharomyces cerevisiae is sensitive to low concentrations of the...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-13 | E-GEOD-54951 | biostudies-arrayexpress
TranscriptomicsHeme-Bound Iron Activates Placenta Growth Factor via Erythroid KrM-CM-
We have tested the effect of iron on the gene expression profile in human leukemia cells with properties of erythroid differentiation. 12 Total samples were analyzed. We compared the gene expression profiles of cells treated with iron mesoporphyrin to mesoporphyrin alone. DMSO vehicle was also teste...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-52087 | biostudies-arrayexpress
TranscriptomicsThe transcriptional regulator Cas5 influences the susceptibility of Candida albicans to Fluconazole.
Azole antifungal agents such as fluconazole exhibit fungistatic activity against Candida albicans. Strategies to enhance azole antifungal activity would be therapeutically appealing. In an effort to identify transcriptional pathways that influence fluconazole susceptibility, we sought to identify ...
ORGANISM(S): Candida albicans 
2014-05-24 | E-GEOD-57930 | biostudies-arrayexpress
MetabolomicsDivergent relationships between faecal microbiota and metabolome following distinct antibiotic-induced disruptions
The intestinal microbiome plays an essential role in regulating many aspects of host physiology, and its disruption through antibiotic exposure has been implicated in the development of a range of serious pathologies. The complex metabolic relationships that exist between members of the intestinal m...
2017-03-03 | MTBLS422 | MetaboLights
UnknownDual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents.
Not available
S-EPMC11744766 | biostudies-literature
TranscriptomicsIdentification of the Candida albicans Cap1p regulon (Cap1-CSE-HA and Cap1-HA complete datasets)
Cap1p, a transcription factor of the basic region-leucine zipper family, regulates oxidative stress response (OSR) in Candida albicans. Alteration of its C-terminal cysteine-rich domain (CRD) results in Cap1p nuclear retention and transcriptional activation. To better understand the function of Ca...
ORGANISM(S): Candida albicans 
2010-05-18 | E-GEOD-15104 | biostudies-arrayexpress
UnknownCo-occurrence of Acheulian and Oldowan artifacts with Homo erectus cranial fossils from Gona, Afar, Ethiopia.
Not available
S-EPMC7056306 | biostudies-literature
TranscriptomicsTolerogenic dendritic cells protect against acute kidney injury
We use tolDCs from syngeneic (C57BL6) and allogeneic (BALB/c) mice to show potent renoprotective abilities in a ischemia reperfusion AKI model. Dendritic cells were derived from mice bone marrow and cultured for 7 days with GM-CSF and IL-4. Tolerogenic DCs were cultured in the same DC media but with...
ORGANISM(S): Mus musculus 
2024-11-25 | E-MTAB-14618 | biostudies-arrayexpress
ProteomicsHuman iPSCs differentiated into SMCs
Human iPSCs were differentiated towards an induced-SMC (iSMC) phenotype in a 10-day protocol. Proteomics was performed throughout the entire differentiation time course to provide a robust, well-defined starting and ending cell population. Proteomics data verified iPSC differentiation to iSMCs. Prot...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032353 | Pride
Calcification Smooth muscle cell Lumos 
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