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ProteomicsDIPG harbour alterations targetable by MEK inhibitors, with acquired resistance mechanisms overcome by combinatorial inhibition
The survival of children with DIPG remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment failure. In a prospective biopsy-stra...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD019701 | Pride
Lc-msms Tmt Clinical Dipg 
TranscriptomicsGene Set Enrichment Analysis reveals lineage relationships between mouse and human gliomas and identifies stem cells and PNET as distinct entities
Murine and human genome-wide microarray expression profiles (including GSE19404) were compared using Partek and Gene Set Enrichment Analysis (GSEA) in order to identify similarities. A murine PNET-like tumour by morphology was found to resemble human ATRT, whereas experimental glioma resembled a par...
ORGANISM(S): Mus musculus 
2013-07-29 | E-GEOD-42515 | biostudies-arrayexpress
TranscriptomicsLongitudinal scRNAseq profiling of memory B cells in mRNA vaccinated individuals post BA.1-breakthrough infection
Memory B cells play a fundamental role in host defenses against viruses. This dataset aimed at understanding the recruitment and remodeling of the memory B cell repertoire in the context of BA.1-breakthrough infection in BNT162b2 mRNA vaccinated individuals. All four donors enrolled in the study had...
ORGANISM(S): Homo sapiens 
2023-08-15 | E-MTAB-12651 | biostudies-arrayexpress
TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
GenomicsGenotype - samples
PNET genotyping
EGAD00010000260 | EGA
GenomicsMolecular Sub-grouping of CNS-PNET
In our study we aimed to define CNS-PNET subgroups. We performed Expression, Genotyping and/or Immunohistochemistry on 142 samples from 20 worldwide centers. Using these techniques, we have identified three molecular subgroups with distinct expression and copy number patterns, as well as, unique c...
EGAS00000000116 | EGA
GenomicsAnnie Huang and the Hospital for Sick Children
Data Access Committee EGAC01000000015
EGAC01000000015 | EGA
UnknownRest-Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study.
Not available
S-EPMC6235690 | biostudies-literature
UnknownThe Future of Blood Testing Is the Immunome.
Not available
S-EPMC8005722 | biostudies-literature
UnknownA systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
Not available
S-EPMC7166077 | biostudies-literature
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