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ProteomicsProteomics on Inhibition of ceramide synthesis in the context of cachexia
Cachexia is a metabolic wasting syndrome affecting most of cancer patients. Disturbed lipid metabolism is a cachexia hallmark, and our previous work has identified increased levels of circulating ceramides, bioactive lipids with established functions in metabolic diseases, as biomarkers for cachexia...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-24 | PXD062072 | Pride
ProteomicsMaintenance of β-cell identity through the transcription co-factors TBL1X and TBL1XR1
Diabetes occurs because of inadequate insulin secretion from pancreatic β-cells, relative to insulin requirements. One mechanism explaining β-cell malfunction in diabetes is their loss of identity, maintained by a series of well-defined transcription factors, which activate the transcription of β-ce...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-25 | PXD054677 | Pride
Transcriptional control Tbl1xr1 Cell identity Β-cells Differentiation Pax6 Tbl1x Insulin Diabetes 
TranscriptomicsTranscriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue
Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-43658 | biostudies-arrayexpress
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