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ProteomicsTCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer in near-clinical models
Triple-negative breast cancer (TNBC) shows an urgent need for new therapies. We discovered Ropporin-1 (ROPN1) as a target to treat TNBC with T-cells. ROPN1 showed high and homogenous expression in 90% of primary and metastatic TNBC but not in healthy tissues. HLA-A2-binding peptides were detected vi...
ORGANISM(S): Homo sapiens (Human) 
2024-08-30 | PXD055042 | Pride
Immunopeptidomics Ropporin-1 
ProteomicsTCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer in near-clinical models
Triple-negative breast cancer (TNBC) shows an urgent need for new therapies. We discovered Ropporin 1 (ROPN1) as a target to treat TNBC with T-cells. ROPN1 showed high and homogenous expression in 90% of primary and metastatic TNBC but not in healthy tissues. HLA-A2-binding peptides were detected v...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054804 | Pride
Adoptive t-cell therapy  cross-reactivity  epitopes  gene-engineering  immunopeptidomics  ropporin-1  t-cell receptor  triple negative breast cancer  tumor-restricted antigen 
UnknownTCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer.
Not available
S-EPMC11609630 | biostudies-literature
UnknownRopporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses.
Not available
S-EPMC8069442 | biostudies-literature
ProteomicsProteomics reveals protein signatures and steroidogenic pathways underlying gonadal sex differentiation in Sinonovacula constricta
The razor clam Sinonovacula constricta is an economically important cultured mollusk in China, but the molecular mechanism of its gonadal development and sexual differentiation remains unclear. In this study, proteomic analysis of gonadal tissues was performed to identify key sex‑biased proteins. A ...
ORGANISM(S): Sinonovacula Constricta 
2026-07-21 | PXD081434 |
UnknownBeyond PKA: Evolutionary and structural insights that define a docking and dimerization domain superfamily.
Not available
S-EPMC8339350 | biostudies-literature
ProteomicsThe role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency
Testosterone is essential to maintain qualitative spermatogenesis. Nonetheless, no studies have been yet performed in humans to analyze the testosterone-mediated expression of the sperm proteins and their importance in reproduction. Thus, this study aimed to identify sperm protein alterations in mal...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD032270 | Pride
Proteomics Hypogonadism Tmt Lh deficiency Male infertility Sperm Testosterone 
Unknown<i>ROPN1</i> Gene Expression as a Prognostic and Predictive Biomarker in Aggressive Breast Cancer: Clinical Implications and Survival Association.
Not available
S-EPMC12462725 | biostudies-literature
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