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ProteomicsHDX-MS Analysis of RORg:RORE:SRC3 Complexes
The retinoic acid receptor-related orphan receptor γ (RORγ) is a ligand-dependent transcription factor that both underpins metabolic and immune functions and provides vantage to manipulate those processes pharmacologically. Despite its importance, our understanding of the ligand-dependent activities...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025765 | Pride
Protein-dna interaction Rorg Rorg response elements Hydrogen deuterium exchange mass spectrometry Protein-protein interaction Src3 
TranscriptomicsYeast zeta-crystallin: An AU-Rich Element Binding Protein Involved in the Nutritional Stress Response
The yeast M-NM-6-crystallin Zta1p interacts specifically with RNA sequences rich in adenine and uracil (AU-rich element). We have looked for possible targets of Zta1p through a comparative transcriptional analysis of the yeast defective in ZTA1 (M-NM-^Tzta1) versus the wild-type by microarray. This ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-02-27 | E-GEOD-45297 | biostudies-arrayexpress
ProteomicsXL-MS of RORg:RORE:SRC3 Complexes
The retinoic acid receptor-related orphan receptor γ (RORγ) is a ligand-dependent transcription factor that both underpins metabolic and immune functions and provides vantage to manipulate those processes pharmacologically. Despite its importance, our understanding of the ligand-dependent activities...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025728 | Pride
Orphan nuclear receptor Dna binding Ligand binding Rorg Protein-protein interactions 
TranscriptomicsDistinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Rheb, a ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in regulation of cell growth depending on extracellular conditions. Fission yeast Rheb regulates amino acid uptake as well as response to nitrogen starvation. In this study we generated two muta...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-28 | E-GEOD-14626 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Rapamycin treatment in yeast cells lacking the Ptc1 protein phosphatase.
We are interested in the study of the already reported sensitivity of yeast cells lacking the type 1 protein phosphatase Ptc1 to the drug rapamycin. In order to carry out our studies, we analyzed the changes in the transcription profile that a short-term incubation with rapamycin (200 ng/mL) has in ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-31 | E-GEOD-11530 | biostudies-arrayexpress
TranscriptomicsGenome-wide map of spliced-leader-led trans-splice sites in Oikopleura dioica
Polycistronic mRNAs transcribed from operons are resolved via the trans-splicing of a spliced leader (SL) RNA. The SL is also frequently trans-spliced to monocistronic transcripts. Using a modified cap analysis of gene expression (CAGE) protocol we mapped sites of SL trans-splicing genome-wide in th...
ORGANISM(S): Oikopleura dioica 
2015-01-26 | E-GEOD-50849 | biostudies-arrayexpress
TranscriptomicsAnalysis of ToxT regulon in Vibrio cholerae El Tor
Using a combination of ChIP-seq and RNA-seq we show that ToxT regulates expression of the small RNA TarB. TarB modulates the expression level of the transcriptioanl repressor VC0177. VC0177 controls expression of several genes including VC0179. The function of the Vibrio 7th pandemic island-1 (VSP-1...
ORGANISM(S): Vibrio cholerae O1 str. C6706 
2012-04-13 | E-GEOD-36373 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of Fhl1 and Ifh1 +/- Rapamycin
Array design -Platform: amino-silane coated glass slides (GAPS II, Corning) -S. cerevisiae intergenic regions amplified from S288C genomic DNA (ResGen) using the intergenic region primer oligonucleotides (ResGen) (Harismendy et al. EMBO J. 22(18): 4738-4747, 2003). The primers allow the amplificati...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-1944 | biostudies-arrayexpress
GenomicsCharacterization of the HNS Regulon Vibrio cholerae El Tor
The transcriptional factor ToxR initiates a virulence regulatory cascade required for V. cholerae to express critical host colonization factors and cause disease. Genome-wide expression studies suggest that ToxR regulates many genes important for V. cholerae pathogenesis, yet our knowledge of the di...
ORGANISM(S): Vibrio cholerae O1 str. C6706 
2016-03-23 | E-GEOD-72471 | biostudies-arrayexpress
GenomicsCharacterization of the TcpP Regulon Vibrio cholerae El Tor
The transcriptional factor ToxR initiates a virulence regulatory cascade required for V. cholerae to express critical host colonization factors and cause disease. Genome-wide expression studies suggest that ToxR regulates many genes important for V. cholerae pathogenesis, yet our knowledge of the di...
ORGANISM(S): Vibrio cholerae O1 str. C6706 
2016-03-23 | E-GEOD-72472 | biostudies-arrayexpress
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