Sort   by:  
 Page size 
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
ProteomicsWDR5 protein interactions at the WIN-site
The WIN site of WDR5 is a druggable pocket that impairs WDR5 protein function and carries therapeutic potential for treating cancer. This study evaluates the protein interactions affected by small molecule blockade of this surface on WDR5. Inhibited and uninhibited WDR5-containing complexes from HEK...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD019209 | Pride
Silac Wdr5 Immunoprecipitation Signaling Chromatin 
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
ProteomicsProteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition
WIN Site inhibitors bind the WIN Site of WDR5 resulting in decreased transcription of WDR5 target genes, many of which encode components of the protein synthesis machinery. In this study, we determined proteome alterations in an MLL-rearranged leukemia cell line treated for either 24 or 72 hours wit...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD035129 | Pride
Proteomics Acute myeloid leukemia Ribosome Wdr5 Label-free quantification Chromatin Translation 
ProteomicsProteome of DiFi EVs, exomeres and supermeres purified by ultracentrifugation and FPLC
The cell seretome is diverse and contains extracellular secreted vesicles (EVs) as well as non-vesicular extracellular nanoparticles (NVEPs) called exomeres and supermeres, all of which carry different kinds of cell signaling cargos. We have developed new techniques to purify exomeres and supermeres...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD066872 | Pride
Supermeres Exosomes Ultracentrifugation Fplc Proteomics Exomeres Extracellular vesicles 
MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
Sort   by:  
 Page size