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TranscriptomicsTranscriptional responses of mouse adipocytes during insulin resistance
Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is k...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-62635 | biostudies-arrayexpress
GenomicsCharacterizing the profiles of histone markers in mouse adipocytes during insulin resistance
Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is k...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-58491 | biostudies-arrayexpress
ProteomicsInflammation causes insulin resistance via IRF3-mediated reduction in FAHFA levels
Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the endogenous FAHFA hydrolase androgen induced gene 1...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-14 | PXD047864 | Pride
Mouse Irf3 Aig1 Inflammation Adipocytes Glucose metabolism High-fat diet Fahfa 
GenomicsEpigenomic profiling of hASC adipogenesis
hASC pre-adipocyte cells were grown to confluence and induced to differentiate in adipogenic media. Examination of 6 histone modifications and CTCF at 4 time points and PPARG at 1 time point using ChIP-Seq
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-21366 | biostudies-arrayexpress
GenomicsEpigenomic profiling of 3T3-L1 adipogenesis
3T3-L1 pre-adipocyte cells were grown to confluence and induced to differentiate in adipogenic media. Examination of 6 histone modifications and CTCF at 4 time points and PPARG at 1 time point using ChIP-Seq
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-21365 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human adipose stromal cell (hASC) adipogenesis
Human abdominal adipose tissue was obtained with informed consent from a 33-year old Caucasian female (BMI = 32.96 Kg/m2) undergoing lipoaspiration. Adipose stromal cells (hASCs) were isolated and differentiated into adipocytes in vitro. Two technical replicates from 9 time points realtive to induct...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-20697 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of human adipose stromal cell (hASC) adipogenesis
Human abdominal adipose tissue was obtained with informed consent from a 33-year old Caucasian female (BMI = 32.96 Kg/m2) undergoing lipoaspiration. Adipose stromal cells (hASCs) were isolated and differentiated into adipocytes in vitro. Two technical replicates from 9 time points relative to induct...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-20699 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 3T3-L1 adipogenesis
3T3-L1 pre-adipocyte cells were grown to confluence and induced to differentiate in adipogeneic media. Two technical replicates from four time points relative to induction of adipogenesis (day 0)
ORGANISM(S): Mus musculus 
2010-09-30 | E-GEOD-20696 | biostudies-arrayexpress
GenomicsCharacterizing the profiles of Ebf1 in mouse fat cells (ChIP-seq)
ChIP-seq data from mouse adipocyte. Mature 3T3-L1 adipocytes were cross-linked with 1% formaldehyde 10 days after induction with MDI. Frozen cell pellets were submitted to the Broad Institute for subsequent analysis of Ebf1-bound regions using anti-Ebf1 antibody (Abnova H00001879-M01).
ORGANISM(S): Mus musculus 
2014-06-10 | E-GEOD-58330 | biostudies-arrayexpress
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