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TranscriptomicsRNA-sequencing based transcriptome-wide expression profiling of Cynomolgus monkey and human IPSCs in vitro differentiated into endothelial cells
We report a macaque in vitro endothelial cell system using induced pluripotent stem cells (IPSCs) from Cynomolgus monkey (Macaca fascicularis). Based on a protocol adapted for human IPSCs we directly differentiated macaque IPSCs into endothelial cells under chemically defined conditions. The resulti...
ORGANISM(S): Homo sapiens Macaca fascicularis 
2016-07-15 | GSE84385 | GEO
TranscriptomicsTranscription profiling of rat livers treated with pharmaceutical development compounds
We used microarrays to analyze gene expression changes in liver after treatment of rats with two compounds from drug development (R1, R2) to identify potential effects related to hepatotoxicity. Experiment Overall Design: Compound R1 or R2, or vehicle control, was given for either 24h or 2 weeks (33...
ORGANISM(S): Rattus norvegicus 
2009-08-09 | E-GEOD-17388 | biostudies-arrayexpress
TranscriptomicsDiet and phenobarbital affect cholesterol homeostasis and drug metabolism
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were analyzed using Sterolgene v0 cDNA microarrays. Sterolgene microarray is a tool designe...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-6447 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with phenobarbital and fed a high cholesterol diet an
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were anayzed using Affymetrix GeneChip MOE430A. Experiment Overall Design: One group of mic...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6721 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver exposed to 24h cytokine starvation vs. treatment with TNF alpha
Pathogenesis of atherosclerosis results from the interactions between disrupted lipid homeostasis and immune response but the molecular bridges between the major players are still a matter of controversy. We investigated the systemic effect of inflammatory cytokine tumor necrosis factor alpha (TNF-Î...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6317 | biostudies-arrayexpress
TranscriptomicsmRNA expression data for rat liver treated for 24h with RG3487 (180mg/kg po.) vs vehicle only (deionized water)
Gene expression analysis followed by gene onthology pathway analysis revealed that “cell cycle” and “growth and proliferation” pathways were significantly affected in the high dose group at the 24h time point. No consistent gene expression changes related to nuclear receptor activation, in particula...
ORGANISM(S): Rattus norvegicus 
2015-08-26 | E-GEOD-72357 | biostudies-arrayexpress
ProteomicsDistinct Extracellular Matrix Protein Signatures of Cortical and Cancellous Bone Allografts Following Processing for Clinical Use
Demineralized bone matrices (DBMs) are widely used in bone replacement therapy. Bone tissue of either cancellous or cortical origin is decellularized, demineralized, and sterilized during processing, while retaining portions of native organic extracellular matrix (ECM) proteins that regulate cell-ma...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD075611 | Pride
GenomicsRNA-sequencing based transcriptome-wide expression profiling of Cynomolgus monkey and human IPSCs in vitro differentiated into endothelial cells
RNA-sequencing based transcriptome-wide expression profiling of Cynomolgus monkey and human IPSCs in vitro differentiated into endothelial cells
PRJNA329031 | ENA
ProteomicsMonitoring global protein thiol-oxidation and protein S-mycothiolation in Corynebacterium diphtheriae under hypochlorite stress
Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol perox...
ORGANISM(S): Corynebacterium diphtheriae 
2017-07-17 | PXD003321 | Pride
Oxicat Corynebacterium diphtheria S-mycothiolation Bacteria Oxidative stress Mycothiol 
GenomicsDynamics of genomic clones in breast cancer patient xenografts at single cell resolution
Human cancers, including breast cancers, are comprised of clones differing in mutation content that evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment i...
EGAS00001000952 | EGA
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