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rs2431697 is a SLE risk SNP, genetic and epigenomic analysis indicate that rs2431697-containing region is an enhancer region. To test the function and regulated genes of rs2431697-containing genes, we deleted rs2431697-containing region in U-937 cells, and performed the RNA-seq to detect the gene ex...
ORGANISM(S): Homo sapiens 
RNA seq in U-937 cells wildtype clones and rs2431697 region deletion clones
To test the genomic region containing rs2431697 whether forms a cognate enhancer-promoter loop with the miR-146a promoter and modulates the expression of miR-146a, we perfomed 4C-seq in U-937 cell line based on the rs2431697 view point and miR-146a promoter view point.
ORGANISM(S): Homo sapiens 
4C-Seq identify the interaction between miR-146a promoter and rs2431697-containing region
4C-Seq identify the interaction between miR-146a promoter and rs2431697-containing region
we performed DNA-affinity precipitation assay (DAPA) followed by mass spectrometry to identify the possible candidates that specifically bind to the 41-bp nucleotide sequence containing rs2431697 using U-937 cell nuclear extracts.
ORGANISM(S): Homo sapiens (Human) 
2020-12-14 | PXD021334 | Pride
we performed DNA-affinity precipitation assay (DAPA) followed by mass spectrometry to identify the possible candidates that specifically bind to the 41-bp nucleotide sequence containing rs2431697 using U-937 cell nuclear extracts.
ORGANISM(S): Homo sapiens (Human) 
2020-11-04 | PXD021335 | Pride
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