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Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysis-targeting chimeras (PROTACs) have emerged as promising alternatives to traditional inhibition. How...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-13 | PXD058734 | Pride
The SWR1 complex replaces the canonical histone H2A with the variant H2A.Z (Htz1 in yeast) at specific chromatin regions. This dynamic alteration in nucleosome structure provides a molecular mechanism to regulate transcription. Here we analysed the transcription profiles of single and double mutants...
ORGANISM(S): Saccharomyces cerevisiae 
The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spon...
ORGANISM(S): Mus musculus 
The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. ...
ORGANISM(S): Mus musculus 
The project presents an in vivo mouse model coupled with quantitative SWATH-MS proteomics to study the early stages of Fasciola hepatica migration, focusing on the parasite's passage through the intestinal barrier to peritoneum(24 hours post-infection) and migration to the liver parenchyma (8 days p...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2025-06-05 | PXD059684 | Pride
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