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ProteomicsBRD4 degradation via stabilization of a native interaction with DCAF16
Targeted protein degradation is a modality based on small molecules that induce proximity between a protein of interest (POI) and an E3 ubiquitin ligase, thus prompting POI ubiquitination and degradation. To expand the reach of TPD, current research is geared to unlock novel E3s. To that end, the tr...
ORGANISM(S): Homo sapiens (Human) 
2024-01-08 | PXD040570 | Pride
Brd4 degradation Kbm7 Small molecule induced proximity Chemical proteomics Gne-0011 Protac Orbitrap fusion lumos Lc-ms/ms 
ProteomicsDiscovery of molecular glue degraders via isogenic morphological profiling
Molecular glue degraders (MGDs) are small molecules that degrade proteins-of-interest via the ubiquitin-proteasome system. Historically, MGDs were discovered serendipitously. Current approaches for MGD discovery include cell-viability based drug screens or data mining of public transcriptomics and d...
ORGANISM(S): Homo sapiens (Human) 
2023-11-20 | PXD045892 | Pride
Neo-substrate Cereblon Targeted protein degradation Molecular glue degrader E3 ubiquitin ligase 
ProteomicsProtein palmitoylation and sphingolipid metabolism cooperatively 1 control regulated exocytosis in cytotoxic lymphocytes
The cytotoxic activity of lymphocytes is particularly dependent on the regulated and polarised delivery of lytic granules to infected or malignant cells. Although genetic and mechanistic studies have identified a number of factors that regulate exocytosis in cytotoxic lymphocytes, a systematic mappi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD045419 | Pride
Exocytosis Nk cells Palmitoylation 
ProteomicsPharmacological perturbation of the phase-separating protein SMNDC1
SMNDC1 is an essential splicing factor that, like its better-studied paralog SMN, binds to di-methylated arginines using its Tudor domain. The specific contributions of the SMNDC1 Tudor domain to protein-protein interactions, subcellular localization, and molecular function have not been studied in ...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-04 | PXD037092 | Pride
Pancreatic alpha cells Tudor domain Small molecule inhibitor Nmr structure Nuclear speckles Splicing Chemical screening 
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