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UnknownCombined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.
Not available
S-EPMC4669588 | biostudies-literature
ProteomicsTitle Page Cardiac Gene Therapy Rescues Diabetic Cardiomyopathy and Lowers Blood Glucose
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intra-cardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes induced H...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044236 | Pride
Calcium handling Transverse-tubule microdomain Gene therapy Glucose uptake Diabetic cardiomyopathy 
TranscriptomicsTranscription profiling of mouse C2C12 myotubes treated overnight with 500 uM palmitate or 1% bovine serum albumin control to identify mediators of obesity-linked reductions in PGC-1
To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes. While overnight exposure to high insulin, glucose, glucosamine, or amino acids had no effect, saturated fatty acids (FA) potently reduced PGC-1a and b mRNA expression. Exper...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6766 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the proteins co-purified with FLAG-HA Non-Stop FLAG-IPed from Drosophila melanogaster S2 cells
Protein Complexes Purification- Drosophila S2 cells were stably-transfected with pRmHa3-based inducible expression vectors to produce epitope-tagged Non-stop-2xFLAG-2xHA (Non-stop-FH). Cells stably transfected with empty vector served as negative control. Protein complexes containing Non-stop were p...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2018-07-17 | MSV000082625 | MassIVE
UnknownPD-016Current results of a phase I study of DKN-01 in combination with paclitaxel (P) in patients (pts) with advanced DKK1+ esophageal cancer (EC) or gastro-esophageal junction tumors (GEJ)
Not available
S-EPMC4984164 | biostudies-literature
ProteomicsMCU activity compensates for Complex I dysfunction
Co-immunoprecipitation experiments were performed in HEK293T cells in the absence and presence of Flag-tagged MCU and binding proteins were identified by tandem mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD018742 | Pride
Mitochondria Label-free Heart Co-ip Lc-ms/ms 
ProteomicsHistone H4K20 Trimethylation is Decreased in Murine Models of Heart Disease
Heart disease is the leading cause of death in the developed world, and its comorbidities such as hypertension, diabetes, and heart failure are accompanied by major transcriptomic changes in the heart. During cardiac dysfunction, which leads to heart failure, there are global epigenetic alterations ...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031617 | Pride
Mouse Sham Lysate Lvad Wt Po 
ProteomicsEFHD1 promotes hepatocyte injury in metabolic liver disease by triggering Ca2+-dependent mitochondrial fission
Human genome-wide association studies (GWAS) of metabolic-associated steatohepatitis (MASH), the most common liver disease worldwide, have examined either liver injury biomarkers or liver fat content, with lipid metabolism enzymes ranked highly in both analyses. Here, to define pathophysiological pa...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-30 | PXD069152 | Pride
Mouse Efhd1 Liver Mash 
ProteomicsProteomic Characterization of Cardioprotective Human Acellular Amniotic Fluid
Amniotic fluid-derived products are a promising resource for cell therapy and tissue engineering due to their anti-inflammatory, angiogenic, and antifibrotic properties. Human amniotic fluid (hAF) has been used in medical applications such as wound healing, skin disorders, and ophthalmic conditions....
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053775 | Pride
Human Amniotic fluid Proteomics Lc-ms/ms 
UnknownThe Political Consequences of Latino Prejudice against Blacks.
Not available
S-EPMC4888580 | biostudies-literature
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