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UnknownStructure and activity of the DHNA Coenzyme-A Thioesterase from Staphylococcus aureus providing insights for innovative drug development.
Not available
S-EPMC8918352 | biostudies-literature
UnknownStructure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design.
Not available
S-EPMC9937910 | biostudies-literature
ProteomicsProteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting Anti-tubercular drug induced liver injury
In the present study, the proteomics approach identified potential protein signatures with high discriminative ability in TB patients with and without drug-induced liver injury which might play a crucial role in developing Anti-tubercular drug-induced liver injury.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-12 | MSV000088373 | MassIVE
UnknownMetabolomic homeostasis shifts after callus formation and shoot regeneration in tomato.
Not available
S-EPMC5421760 | biostudies-literature
MetabolomicsMetabolomic homeostasis shifts after callus formation and shoot regeneration in tomato
Plants can regenerate from a variety of tissues on culturing in appropriate media. However, the metabolic shifts involved in callus formation and shoot regeneration are largely unknown. The metabolic profiles of callus generated from tomato (Solanum lycopersicum) cotyledons and that of shoot regener...
2018-06-29 | MTBLS447 | MetaboLights
ProteomicsA Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Molecular Determinants in Redox Homeostasis and NF-κB Signaling
Mitochondrial protein (MP) dysfunction has been linked to neurodegenerative disorders (NDs), however, the discovery of molecular mechanisms underlying NDs has been impeded by the limited characterization of interactions governing MP function. Here, using 109 affinity-purified mitochondrial fractions...
ORGANISM(S): Homo sapiens (Human) 
2017-12-05 | PXD006690 | Pride
Parkinson's disease Autism Mitochondria Nf-kb signaling Mitochondrial proteins Neurodegeneration Protein-protein interactions Proteomics 
ProteomicsGlobal Landscape of Cell Envelope Protein Complexes in Escherichia coli
After extraction with mild non-denaturing detergents, we affinity-purified 785 endogenously-tagged CEPs and then identified stably-associated polypeptides by precision mass spectrometry. The resulting high-quality physical interaction network, comprising most (77%) of all targeted CEPs, revealed hu...
ORGANISM(S): Escherichia coli (strain K12 / W3110 / ATCC 27325 / DSM 5911) 
2017-11-30 | PXD006247 | Pride
Escherichia coli Multi-protein complexes Macromolecues Protein-protein interactions Cell envelope Cell envelope proteins Cell envelope protein complexes 
ProteomicsThe Conserved Tpk1 Regulates Non-Homologous End Joining Double-Strand Break Repair by Phosphorylation of Nej1, a Homolog of the Human XLF
The yeast cyclic-AMP dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits rema...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024695 | Pride
Genomic instability Prkacb Nhej Tpk1 Dsb repair Nej1 Kinase 
ProteomicsThe Conserved Tpk1 Regulates Non-Homologous End Joining Double-Strand Break Repair by Phosphorylation of Nej1, a Homolog of the Human XLF
The yeast cyclic-AMP dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits rema...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024768 | Pride
Genomic instability Prkacb Nhej Tpk1 Dsb repair Nej1 Kinase 
ProteomicsMitochondrial Network Organization during Neuronal Reprogramming, MT_UDF_SEC
The study focuses on an extensive biochemical fractionation with in-depth quantitative mass spectrometric profiling in the mitochondrial (mt) extracts of cultured human NTera2 embryonal carcinoma stem cells (i.e. ECSCs or undifferentiated state) and upon exposure to retinoic acid-induced differentia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD009834 | Pride
Biochemical fractionation  ci and civ deficiencies  differentiated neuronal cells  human ntera2 embryonal carcinoma stem cells  mass spectrometry  mitochondrial proteins  mitochondrial interaction landscape  proteomics  protein complexes  patient fibroblasts  neurodegeneration  orphans 
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