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ProteomicsDDX3Y and other Male Specific Region of Y Chromosome Genes may modulate neuronal differentiation and mediate various biological pathways in addition to their well described role regulating spermatogenesis
Human tissue based proteomics projects are challenging due to low abundance of proteins and tissue specificity of protein expression. In this study, we aimed to develop a cell-based approach to profile the male specific region of the Y chromosome (MSY) proteins. First, we profiled the expression of ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083949 | MassIVE
TranscriptomicsComprehensive gene expression analysis of human embryonic stem cell during differentiation into neural cells
In this research we have done a comprehensive transcripteome analysis of hESC differentiation at three different stages: early neural differentiation, neural ectoderm, and mature neurons. We detected and validated time-dependent gene expression patterns and represented that the gene expression patte...
ORGANISM(S): Homo sapiens 
2011-04-15 | E-GEOD-28633 | biostudies-arrayexpress
ProteomicsProteome Analysis of Human Embryonic Stem Cells Organelles
Here, we have utilized a sub-cellular proteomics approach to analyze the localization of proteins in the nucleus, mitochondria, crude membrane, cytoplasm, heavy and light microsomes. Out of 2002 reproducibly identified proteins, we detected 762 proteins in a single organelle whereas 160 proteins wer...
ORGANISM(S): Homo sapiens (Human) 
2017-04-26 | PXD006271 | Pride
Human embryonic stem cells Organelles 
ProteomicsEnrichment, proteome analysis and transplantation of human embryonic stem cell derived dopaminergic progenitors expressing LMX1a
Despite the progress in safety and efficacy of cell therapy with pluripotent stem cells (PSCs), the presence of residual undifferentiated stem cells or proliferating neural progenitor cells (NPCs) with rostral identity has remained a major challenge. Here we reported the generation of an LMX1A knock...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007837 | Pride
Parkinson disease Pluripotent stem cells Quantitative proteomics Hesc 
ProteomicsDDX3Y and other Male Specific Region of Y Chromosome Genes may modulate neuronal differentiation and mediate various biological pathways in addition to their well described role regulating spermatogenesis
Human tissue based proteomics projects are challenging due to low abundance of proteins and tissue specificity of protein expression. In this study, we aimed to develop a cell-based approach to profile the male specific region of the Y chromosome (MSY) proteins. First, we profiled the expression of ...
ORGANISM(S): Homo sapiens (Human) 
2015-09-17 | PXD002428 | Pride
Rna metabolism. Chromosome centric human proteome project (c-hpp) Ddx3y Apoptosis Cell-based human proteome project Cell cycle Shotgun proteomics Y-linked genes 
ProteomicsThe Dynamic Proteome of Oligodendrocyte Lineage Differentiation Features Planar Cell Polarity and Macroautophagy Pathways
Generation of oligodendrocytes (OLs) is a sophisticated multistep process, mechanistic underpinnings of which are not fully understood and demand further investigation. To systematically profile proteome dynamics during human embryonic stem cell (hESC) differentiation into OLs, we applied in-depth q...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD017649 | Pride
Human embryonic stem cell  neural stem cell  progenitor cell  oligodendrocyte  wnt signaling  autophagy  quantitative proteomics  multiplexed tandem mass tag 
ProteomicsCharacterizations of molecularly distinct subpopulations of conditioned medium derived extracellular vesicles prior to be used as medicinal product
Mesenchymal stromal cells (MSCs) derived EVs are greatly studied in disease models but lack of manifested characterization rather than generic EVs characterization in different EV subpopulations, greatly limits our ability to bring the most reliable EV types into our studies. We provide a comparativ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD022174 | Pride
Extracellular vesicles Mesenchymal stromal cells Subpopulations 
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