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ProteomicsProteomic profiling of saliva, salivary stones and kidney stones reveals candidate biomarkers of pathological calcification
Formation of salivary stones, a rare pathological condition, currently lacks non-surgical treatment options. The underlying causes remain unknown, although one hypothesis suggests bacterial infections may play a role. To investigate these theories and identify proteins whose altered levels might imp...
ORGANISM(S): Homo sapiens (Human) Raoultella ornithinolytica 
2026-03-11 | PXD069065 | Pride
Proteomics  saliva  salivary stones  kidney stones  biomarkers  biocalcification  sample preparation  sonication 
ProteomicsProteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands.
Salivary stones, also known as sialoliths, are formed in a pathological situation in the salivary glands. So far, neither the mechanism of their formation nor the factors predisposing to their formation are known. Although they do not directly threaten human life, they significantly deteriorate the ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039381 | Pride
Functional analysis Mass spectrometry Sialolithiasis Salivary stones Swath-ms 
UnknownLactoferrin and the development of salivary stones: a pilot study.
Not available
S-EPMC10181970 | biostudies-literature
UnknownNeutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones.
Not available
S-EPMC7564068 | biostudies-literature
UnknownMicrobiomic association between the saliva and salivary stone in patients with sialolithiasis.
Not available
S-EPMC11035639 | biostudies-literature
ProteomicsA comprehensive protein profile analysis from clinical Sialoliths and its practical implications
We analyzed 29 Sialolith samples, employing classical Population Genetic principles (Hartl and Clark 1980 (1), Hahn 2018 (2)) and Systems Biology analysis (ed: by Rigoustsos and Stephanopoulos 2006 (3)) approaches to create specific algorithms designed for our research objectives. Using these method...
ORGANISM(S): Homo sapiens (Human) 
2020-04-16 | PXD012422 | Pride
Protein fraction Disease Salivary duct Human sialoliths 
UnknownAblation of TRPC3 disrupts Ca2+ signaling in salivary ductal cells and promotes sialolithiasis.
Not available
S-EPMC10082769 | biostudies-literature
UnknownSurgical non-aggressive approach for the delivery of 4 cm salivary stone from the submandibular gland duct: Avoiding salivary gland removal - A case report.
Not available
S-EPMC11815691 | biostudies-literature
ProteomicsThe role of metal nanoparticles in the pathogenesis of stone formation
The present work is devoted to the study of morphology and composition of stones obtained as a result of surgical interventions for sialolithiasis The obtained results of clinical and laboratory studies allow us to broaden the view on the pathogenesis of stone formation and suggest that the occurren...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054153 | Pride
Endogenous infections Immunoglobulin Crystallization centers Salivary gland stones Metal nanoparticles Pathogenesis 
UnknownProteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands.
Not available
S-EPMC10035263 | biostudies-literature
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