Sort   by:  
 Page size 
ProteomicsMoving Forward Real-Time Proteomics Mass Spectrometry by Remote Infrared Matrix-Assisted Laser Desorption-Ionization
Novel development makes remote real-time analysis with possible translation to in-vivo a reality. Remote Infrared Matrix Assisted Laser Desorption Ionization (Remote IR MALDI) system with endogenous water as matrix becomes real and allows to envisage real-time proteomics to be performed in the in-vi...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2018-04-20 | PXD008092 | Pride
Mass spectrometry • real-time analysis • remote ir maldi• proteins • charge state distribution 
ProteomicsInhibition of Furin in CAR macrophages directs them towards a pro-inflammatory phenotype and enhances their anti-tumor activities.
Anti-cancer immunotherapy approaches are increasingly coveted. Chimeric antigen receptor (CAR)-T cell therapy has been shown to be an effective treatment for hematological tumors, but the treatment of solid tumors still lacks effectiveness, due to lower intra-tumor infiltration of CAR-T cells and tu...
ORGANISM(S): Homo sapiens (Human) 
2024-12-12 | PXD058491 | Pride
Proprotein convertases Furin Breast cancer Car macrophage Tumoroids 
UnknownEpigenetic Studies Revealed a Ghost Proteome in PC1/3 KD Macrophages under Antitumoral Resistance Induced by IL-10.
Not available
S-EPMC7643081 | biostudies-literature
ProteomicsProteomic analysis of the spatiotemporal based molecular kinetics of acute spinal cord injury identifies a time- and segment-specific window for effective tissue repair - IgG identification
Spinal cord injury (SCI) represents a major debilitating health issue with a direct socioeconomic burden on the public and private sectors worldwide. Although several studies have been conducted to identify the molecular progression of injury sequel due from the lesion site, still the exact underlyi...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-06-08 | PXD004247 | Pride
1d gel Mass spectrometry Igg Spinal cord injury 
UnknownRemote Atmospheric Pressure Infrared Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry (Remote IR-MALDI MS) of Proteins.
Not available
S-EPMC6072536 | biostudies-literature
ProteomicsON-TISSUE DIRECT MONITORING OF GLOBAL HYDROGEN/DEUTERIUM EXCHANGE BY MALDI MASS SPECTROMETRY: TDXMS
Hydrogen/deuterium exchange mass spectrometric methods for protein structural analysis are conventionally performed in solution. We present Tissue Deuterium Exchange Mass Spectrometry (TDXMS), a method to directly monitor deuterium uptake on tissue, as a means to better approximate the deuterium exc...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-08-15 | PXD004630 | Pride
Tissue Mass spectrometry In situ analysis H/d exchange 
ProteomicsLocation of Neonatal Microglia Drives Small Extracellular Vesicles Content and Biological Functions
Combining proteomics and systems biology analyses, we demonstrated that neonatal microglial cells derived from two different CNS locations (cortex and spinal cord) displayed different phenotypes upon different physiological or pathological conditions. These cells also exhibited great variability in ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-26 | PXD016093 | Pride
Exosomes Proteomics Lc-ms Microglia Vesicles 
UnknownEarly Diagnosis: End-to-End CNN-LSTM Models for Mass Spectrometry Data Classification.
Not available
S-EPMC10501374 | biostudies-literature
ProteomicsIntegrated Mass Spectrometry Imaging and Omics Workflows on the Same Tissue Section Using Parafilm-Assisted Microdissection
In this work, we demonstrate the use of grid-aided, parafilm-assisted microdissection to perform MALDI MS imaging and shotgun proteomics and metabolomics in a combined workflow and using only a single tissue section. The grid is generated by microspotting of acid dye 25 using a piezoelectric microsp...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-03-20 | PXD005345 | Pride
Proteomics Lipidomics Maldi ms imaging Parafilm-assisted microdissection 
ProteomicsHistone proteomic associated with epigenetic studies revealed a Ghost proteome in PC1/3 KD macrophages involved in anti - tumoral resistance under IL - 10 stimulation
In our previous work, our investigation on macrophages has allowed us to show that the inhibition of the enzyme proprotein convertase (PC1/3) controls the activation of macrophages. We demonstrated that PC1/3 knockdown (KD) in macrophages would exhibit an increased secretion of pro-inflammatory and ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-02-12 | PXD020610 | Pride
Macrophage Lc-msms Altprots Histone Epigenetic 
Sort   by:  
 Page size