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ProteomicsSAMD1 suppresses epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma.
SAMD1, a CpG island-binding protein, plays a pivotal role in the repression of its target genes by influencing the activity of KDM1A. Despite its significant correlation with outcomes in various tumor types, SAMD1's role in cancer has remained largely unexplored. In this study, we focus on pancreati...
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD044104 | Pride
Cancer Epithelial-mesenchymal transition Cpg islands N-cadherin Fbxo11 Samd1 Kdm1a Chromatin Pancreatic ductal adenocarcinoma 
ProteomicsThe SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands
CpG-islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 possesses an atypical winged-he...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD016781 | Pride
Chromatin Transcription Cpg islands 
UnknownInvestigation of SAMD1 ablation in mice.
Not available
S-EPMC9944271 | biostudies-literature
GenomicsSAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma [RNA-Seq]
SAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma [RNA-Seq]
PRJNA999243 | ENA
GenomicsSAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma [ChIP-Seq]
SAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma [ChIP-Seq]
PRJNA999242 | ENA
GenomicsThe SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status [CUT&RUN]
The SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status [CUT&RUN]
PRJNA1178302 | ENA
GenomicsThe SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status [RNA-seq]
The SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status [RNA-seq]
PRJNA1178301 | ENA
UnknownSAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma.
Not available
S-EPMC11343471 | biostudies-literature
UnknownThe SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status.
Not available
S-EPMC12337194 | biostudies-literature
UnknownSAMD1 attenuates antiphospholipid syndrome-induced pregnancy complications.
Not available
S-EPMC10614121 | biostudies-literature
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