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MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
TranscriptomicsPlasmodium yoelii RNA-Seq
Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins. Dr Tony Holder's laboratory (NIMR, London) has been...
ORGANISM(S): Plasmodium yoelii 
2011-04-25 | E-MTAB-636 | biostudies-arrayexpress
TranscriptomicsNeospora caninum RNAseq
Recent advances in high throughput sequencing methodologies allow the opportunity to probe in depth the transcriptomes of organisms including N. caninum. In this project, we are using Illumina sequencing technology to analyze the transcriptome (RNA-Seq) of experimentally accessible stages (e.g. tach...
ORGANISM(S): Neospora caninum 
2011-02-08 | E-MTAB-549 | biostudies-arrayexpress
TranscriptomicsTrypanosoma vivax Y486 bloodstream stage RNAseq
Trypanosoma vivax is a vector-borne blood parasite of cattle throughout sub-saharan Africa. For some years the genome sequence of this organism has been in development at the Wellcome Trust Sanger Institute and is shortly to be completed. Analysis of the genome has revealed various putative genes en...
ORGANISM(S): Trypanosoma vivax 
2011-02-16 | E-MTAB-475 | biostudies-arrayexpress
TranscriptomicsToxoplasma gondii RNASeq
Recent advances in high throughput sequencing methodologies allow the opportunity to probe in depth the transcriptomes of organisms including N. caninum and Toxoplasma gondii. In this project, we are using Illumina sequencing technology to analyze the transcriptome (RNA-Seq) of experimentally access...
ORGANISM(S): Toxoplasma gondii 
2011-02-08 | E-MTAB-550 | biostudies-arrayexpress
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
ProteomicsComparison of Protein Extraction Methods in Tendon Mass Spectrometry Analysis
Tendons play a fundamental role in the musculoskeletal system and locomotion by transferring forces generated from muscles to the skeleton. Tendon injuries can occur due to sports related incidents, as a result of trauma to overuse or during disease or ageing. Using proteomic techniques tendon prote...
ORGANISM(S): Equus caballus (Horse) 
2018-07-05 | PXD004453 | Pride
Tendon Lc-ms/ms 
TranscriptomicsMalaria Cell Atlas: Single cell transcriptomics of malaria parasites
Single-cell RNA-sequencing is revolutionising our understanding of seemingly homogeneous cell populations but has not yet been widely applied to single-celled organisms. Transcriptional variation in unicellular malaria parasites from the Plasmodium genus is associated with critical phenotypes includ...
ORGANISM(S): Plasmodium falciparum 3D7 
2017-02-08 | E-ERAD-611 | biostudies-arrayexpress
TranscriptomicsSalmonella bongori comparative genome hybridization
Comparative genome hybridization (CGH) of 35 Salmonella bongori strains and 16 Salmonella spp strains belonging to SarC collection
ORGANISM(S): Salmonella enterica 
2010-12-31 | E-TABM-931 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Clostridium sporogenes and Clostridium botulinum strains
Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin, the most poisonous toxin known to man, and the causative agent of botulism, a severe disease of human...
ORGANISM(S): Clostridium botulinum 
2007-05-23 | E-TABM-264 | biostudies-arrayexpress
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