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ProteomicsLabel free quantitative (LFQ) proteomic analysis of mouse lymphatic endothelial cells and primary mouse dendritic cells in response to IFNgamma treatment in presence or absence of 3-HKA
To explore the cellular pathways and the molecular functions affected by a novel biogenic amine, (3-HKA), we performed a label free quantitative (LFQ) proteomic analysis of mouse lymphatic endothelial cells (LEC), and primary dendritic cells, treated with IFNgammaplus or minus 3-HKA. Biological tri...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-28 | PXD015865 | Pride
Mouse lymphatic endotehlial cells (lec)  mouse primary dendritic cells (pdc)  nanolc-ms/ms 
ProteomicsProteomic Profiling of Cerebrospinal Fluid in Adult Rats with Compromised Lymphatic Drainage Using DIA-PASEF
The glymphatic system’s outflow of “dirty” brain fluids collects in the meningeal lymphatic vessels, which drain via lymphatic collectors primarily to the deep cervical lymph nodes (dcLN). It is unclear, however, whether lymphatic dcLN drainage is a prerequisite for normal cerebral homeostasis. Here...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-04 | PXD063161 | Pride
Cauterized Rat Dia-pasef 
ProteomicsTMT-Based Quantitative Proteomics of Cerebrospinal Fluid Reveals Molecular Signatures of Lymphatic Drainage Impairment in Young Rats
The glymphatic system facilitates the clearance of interstitial solutes and waste products from the brain parenchyma, channeling them into the meningeal lymphatic vessels for subsequent drainage into the deep cervical lymph nodes (dcLNs). However, the extent to which this lymphatic outflow via dcLNs...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-04 | PXD063564 | Pride
Dc-ln cauterization Csf 
ProteomicsLabel free-DDA nano-LC/MS/MS analysis of Human Mesenteric lymph collected from Inflammatory Bowel Disease (IBD) subjects.
Compromise of the intestinal barrier have been associated with a series of inflammatory conditions where the routine controls nutrient absorption and pathogens exclusion is lost to different degrees. The intestinal epithelial cells form a barrier of selective permeability which protects from invasio...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044801 | Pride
Lable free-dda Lymphatics Inflammatory bowel disease Lymph 
ProteomicsLabel-free quantitative data dependent (DDA) nano-LC-MS/MS analysis of proteomic changes in the mesenteric lymph harvested from healthy (control) and DSS-fed mice models of colitis
The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens can interact with the host immune system. Intestinal barrier defects have been linked to a broad range of pathological states, including autoimmune, cancer and neurodegenerative diseases....
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD044885 | Pride
Mouse mesenteric lymph  dda nano-lc/ms/ms 
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice using a combination of data-dependent (DDA) and data-independent acquisition (DIA) nanoLC mass spectrometry
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD023581 | Pride
Mouse dendritic cells  i-ab mhc-ii immunopeptidome  dda and dia nanolcms 
ProteomicsNano LC-MS/MS DDA mass spectrometry profiling of I-Ab MHCII immunopeptidome eluted from B6 mice on normal and high fructose/high fat (HFHF) diet
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-22 | PXD026068 | Pride
Mouse i-ab immunopeptidome  dda nanolc-ms/ms  orbitrap fusion tribrid mass spectrometer 
ProteomicsLabel-free comparative data dependent (DDA) nanoLC-MS/MS analysis of redox mediated posttranslational modifications (PTMs) in the proteomes from mouse primary dendritic cells (DC) isolated from control B6 and obese (Ob/Ob) mice
Proteomic modifications linked to non-enzymatic glycation and glycoxidation are common in all tissues under hyperglycemic conditions, as present in metabolic syndrome, type 2 diabetes (T2D), mice bearing a homozygous mutation in leptin (so-called Ob/Ob mice, a common model of obesity and T2D) and mi...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD024239 | Pride
Control b6 and ob/ob mice dendritic cells Bottom-up proteomics on qehf and velos orbitrap 
ProteomicsLabel-free comparative data independent (DIA) nanoLC-MS/MS analysis of protein expression profiles of mouse primary dendritic cells (DC) from B6 mice on normal and high fructose/high fat (HFHF) diet
A diet rich in saturated fat and carbohydrates causes a low-grade chronic inflammation in several organs including nonalcoholic steatohepatitis. The environment-driven lipotocicity and glucotoxicity induce tissue damage, which promotes dendritic cell adjuvanticity, and supports an MHC-class-II immun...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-22 | PXD026190 | Pride
Mouse dendritic cells (cd11c+) proteomics  dia/dda nano lc-ms/ms orbitrap fusion tribrid mass spectrometer 
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice (2)
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD018783 | Pride
Mouse i-ab mhcii peptidome  lc/ms/ms dda on qe mass spectrometer 
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