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MetabolomicsA red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition

BACKGROUND: Gut microbiota profiles are closely related to cardiovascular diseases through mechanisms that include the reported deleterious effects of metabolites, such as trimethylamine N-oxide (TMAO), which have been studied as diagnostic and therapeutic targets. Moderate red ...

2024-05-09 | MTBLS310 | MetaboLights
TranscriptomicsExpression data from Saccharomyces cerevisae strains deleted for the RNA-binding hnRNP Npl3
Transcription is a major obstacle for replication fork progression and a cause of genome instability. Such instability increases in mutants with a suboptimal assembly of the nascent messenger ribonucleo-protein particle (mRNP), as THO/TREX and some heterogeneous nuclear ribonucleoproteins (hnRNPs) m...
ORGANISM(S): Saccharomyces cerevisiae 
2013-11-15 | E-GEOD-50186 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells and primordial germ cells to identify genes up-regulated in pluripotent cells
Understanding the transcriptional regulation of pluripotent cells is of fundamental interest and will greatly inform efforts aimed at directing differentiation of embryonic stem (ES) cells or reprogramming somatic cells. We first analyzed the transcriptional profiles of mouse ES cells and primordial...
ORGANISM(S): Mus musculus 
2007-07-28 | E-MEXP-1158 | biostudies-arrayexpress
MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
TranscriptomicsHealthy Antrum miRnome
A small RNA library of stomach antrum tissue was sequenced using high-throughput SOLiD sequencing technology. The study aims to provide complementary information of the role of miRNAs in molecular regulation process in the healthy human stomach, in order to establish a reference for future compariso...
ORGANISM(S): Homo sapiens 
2014-03-26 | E-MTAB-2273 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 30 ovarian cancer cell lines reveals amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer
DNA from 30 cultured ovarian cancer cell lines was extracted with Promega kits and hybridize to arrays. Arrays comprised of 1860 BACs selected to include genes known to be involved in cancer pathogenesis and 400 BACs selected to tile across 13 Mbp at 3q26, 15 Mbp at 8q24, and 30 Mbp at 20q centered ...
ORGANISM(S): Homo sapiens 
2007-06-04 | E-TABM-246 | biostudies-arrayexpress
UnknownRedox activity of nickel and vanadium porphyrins: a possible mechanism behind petroleum genesis and maturation?
Not available
S-EPMC9062163 | biostudies-literature
UnknownA Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil.
Not available
S-EPMC8143327 | biostudies-literature
UnknownDifferential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation.
Not available
S-EPMC5852541 | biostudies-literature
ProteomicsA generic normalization method for proper quantification in untargeted proteomics screening
The label-free quantitative mass spectrometry methods, in particular the SWATH-MS approach, have gained popularity and became a powerful technique for comparison of large datasets. In the present work, it is introduced the use of recombinant proteins as internal standards for untargeted label-free m...
ORGANISM(S): Aequorea victoria Homo sapiens (Human) Escherichia coli Rattus norvegicus (Rat) 
2019-08-19 | PXD009068 | Pride
Internal standard Data normalization Biofluids Proteomics screening Swath-ms 
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