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TranscriptomicsIdentifying conserved and novel miRNAs in developing seeds of Brassica napus using deep sequencing [mRNA-seq]
MicroRNAs (miRNAs) are important post-transcriptional regulators of plant development and seed formation. In Brassica napus, an important edible oil crop, valuable lipids are synthesized and stored in specific seed tissues during embryogenesis. The miRNA transcriptome of B. napus is currently poorly...
ORGANISM(S): Brassica napus 
2014-08-01 | E-GEOD-38018 | biostudies-arrayexpress
TranscriptomicsDecoding the black box of cellulase formation in Hypocrea jecorina by RNA-Seq analysis
Hypocrea jecorina (anamorph Trichoderma reesei) is one of the most well studied fungi used in biotechnology industry. This fungus is today a paradigm for the comercial scale production of different plant cell wall degrading enzymes, mainly cellulases and hemicellulases. The objective of this study w...
ORGANISM(S): Trichoderma reesei 
2014-04-01 | E-GEOD-53629 | biostudies-arrayexpress
TranscriptomicsmiR-155 KO in human dendritic cells
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-deri...
ORGANISM(S): Homo sapiens 
2009-03-04 | E-GEOD-13296 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation
miRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation. Immature, 4h and 16h LPS-activated moDCs were used. In this study were analysed 2 biological samples of RNA extracted from 4h-post LPS stimulation moDCs and 2 bfrom 16h-post LPS stimulation. The RNA ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-13369 | biostudies-arrayexpress
TranscriptomicsTumor exosome integrins determine organotropic metastasis
Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress
TranscriptomicsTranscript profiles of juvenile female brown trout exposed to glyphosate and Roundup herbicides.
This study aimed to investigate the hepatic transcriptional response of brown trout to glyphosate, and its formulated product, Roundup. We exposed juvenile female brown trout to three concentrations of glyphosate (0.01, 0.5 and 10 mg/L) and Roundup (0.01, 0.5 and 10 mg/L glyphosate acid equivalent) ...
ORGANISM(S): Salmo trutta 
2015-04-16 | E-GEOD-56855 | biostudies-arrayexpress
ProteomicsCell-Surface RNA Forms Ternary Complex with RNA-Binding Protein and Heparan Sulfate to Recruit Immune Receptors Complex with RNA-Binding Protein and Heparan Sulfate to Recruit Immune Receptor
Recent discoveries have shown the presence of RNA molecules on the cell surface, defying the traditional view that RNA only functions intracellularly. However, it is not well understood how cell-surface RNA (csRNA) is stably present on the plasma membrane and what functions it performs. We answer th...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD061693 | Pride
Heparane sulfate Immunity Rna Cell surface Rna-binding proteins 
TranscriptomicsDNA-damage induced differentiation of leukemic cells as an anti-cancer barrier
Here we show that the histone methyltransferase MLL4 (Kmt2d) is required for stem cell activity and an aggressive form of acute myeloid leukemia (AML) harboring the MLL-AF9 oncogene. MLL4 exerts its function by regulating transcriptional programs associated with the anti-oxidant response. The role o...
ORGANISM(S): Mus musculus 
2014-07-22 | E-GEOD-57147 | biostudies-arrayexpress
GenomicsFGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency
Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos but the signalling mechanisms that induce reprogramming are unknown. Here we show that inhibition of Erk1/2 and Gsk3bM-BM- signalling in mouse embryonic stem cells (ESCs) by small molecule inhibitors...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-42923 | biostudies-arrayexpress
TranscriptomicsmiRNA transcription profiling in Status Epilepticus Induced Epileptogenic Process
miRNA array comparing the transcription profile of control rats and rats after intra-hippocampal pilocarpine-induced Status Epilepticus (PILO-SE).
ORGANISM(S): Rattus norvegicus 
2016-04-28 | E-MTAB-4633 | biostudies-arrayexpress
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