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Transcriptomics analysis of a zebrafish model of Combined Saposin Deficiency
The objective of this project was to determine the interaction interface(s) between acid beta-glucosidase (GCase) and its activator protein saposin C (SapC). Chemical crosslinking was used to confirm the formation of discrete heterodimers between the two proteins, using lysine-reactive crosslinkers ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058056 | Pride
Combined Saposin Deficiency is a lysosomal storage disease with multiple-organ pathologies that often involve neurodegeneration and early mortality. To investigate the mechanisms driving saposin loss-associated demyelination, the brains of psap-/- zebrafish and wildtype siblings were analyzed via RN...
ORGANISM(S): Danio rerio 
2023-03-18 | GSE227551 | GEO
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