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ProteomicsCombined targeted and untargeted high-resolution mass spectrometry analyses to investigate metabolic alterations in Pompe disease
Pompe disease is a rare, lysosomal disorder, characterized by intra-lysosomal glycogen accumulation due to an impaired function of ?-glucosidase enzyme. The laboratory testing for Pompe is usually performed by enzyme activity, genetic test, or urine glucose tetrasaccharide (Glc4) screening by HPLC. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-07 | MSV000088329 | MassIVE
ProteomicsGlucosidase Alpha Neutral C Promotes Influenza Virus Replication by Inhibiting Proteosome-Dependent Degradation of Hemagglutinin
The H7N9 influenza virus poses a significant threat to human health, and the mechanism by which it infects humans remains incompletely understood. Our investigation has unveiled significant insights into the role of glucosidase alpha, neutral C (ganc) gene in human H7N9 infections. Through whole gen...
ORGANISM(S): Homo Sapiens 
2025-03-10 | PXD061732 |
TranscriptomicsSkeletal muscle gene expression in the wild type and the GAA knock-out mice, a model of Pompe disease
Pompe disease is a Lysosomal glycogen storage disorder due to the deficiency of acid alpha glucosidase. The enzyme degrades glycogen to glucose and its deficiency results in progressive enlargement of glycogen-filled lysosomes in multiple tissues with skeletal and cardiac muscle most severely affect...
ORGANISM(S): Mus musculus 
2017-05-13 | E-GEOD-57980 | biostudies-arrayexpress
GenomicsVibrio. sp strain X95 beta-glucosidase gene, partial cds
Vibrio. sp strain X95 beta-glucosidase gene, partial cds Metagenome
PRJNA624238 | ENA
ProteomicsProteomic study in Pompe disease
The raw data of SWATH proteomic analysis of plasma in Pompe disease patients and controls
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086114 | MassIVE
ProteomicsInteraction of saposin C and acid-beta-glucosidase
The objective of this project was to determine the interaction interface(s) between acid beta-glucosidase (GCase) and its activator protein saposin C (SapC). Chemical crosslinking was used to confirm the formation of discrete heterodimers between the two proteins, using lysine-reactive crosslinkers ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058056 | Pride
Gaucher Lysosome Glucosidase Saposin Crosslinking 
ProteomicsProteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1
Gaucher disease (GD) is caused by the defective activity of acid beta-glucosidase (GCase) which results from mutations in GBA1. Neurological forms of GD (nGD) can be generated in mice by intra-peritoneal injection of conduritol B-epoxide (CBE) which irreversibly inhibits GCase. Using this approach, ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-12 | MSV000092415 | MassIVE
GenomicsA novel ß-glucosidase isolated from the microbial metagenome of Lake Poraquê (Amazon, Brazil)
A novel ß-glucosidase isolated from the microbial metagenome of Lake Poraquê (Amazon, Brazil)
PRJEB23784 | ENA
TranscriptomicsInduction of lignocellulose-degrading enzymes in Neurospora crassa by cellodextrins
Transcriptional profiling with next-generation sequencing methods demonstrated that a Neurospora crassa mutant with the three most highly expressed beta-glucosidase genes deleted had a transcriptional response to cellobiose similair to that of wild type N. crassa exposed to cellulose. N. crassa was ...
ORGANISM(S): Neurospora crassa OR74A 
2012-04-04 | E-GEOD-36719 | biostudies-arrayexpress
UnknownCharacterization of β-glucosidase activity of a Lactiplantibacillus plantarum 6-phospho-β-glucosidase.
Not available
S-EPMC11978721 | biostudies-literature
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