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ProteomicsSAPrIm 2.0: A semi-automated protocol for mid-throughput soluble HLA immunopeptidomics
Human leukocyte antigen (HLA) molecules are pivotal in guiding human adaptive immune responses through their presentation of peptide ligands, collectively known as the immunopeptidome. This process is central to the development of cancer immunotherapies, such as vaccines and T-cell therapies. Profil...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD058880 | Pride
Shla Hla Mass spectrometry Mhc Saprim Immunopeptidomics Soluble hla Plasma immunopeptidomics 
UnknownSAPrIm, a semi-automated protocol for mid-throughput immunopeptidomics.
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S-EPMC10272402 | biostudies-literature
ProteomicsSAPrIm, A Semi-Automated Protocol for mid-throughput Immunopeptidomics
Human leukocyte antigen (HLA) molecules play a crucial role in the development of adaptive immune responses and therefore have been of major interest in the development of immunotherapies such as cancer vaccines and chimeric antigen receptor (CAR) T cells. Hence, a comprehensive understanding and pr...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD041046 | Pride
Immunopeptidomics Human leukocyte antigen Kingfisher 
ProteomicsDimethyl Sulfoxide Enhances HLA Peptide Identification
Immunopeptidomics relies on LC-MS/MS for comprehensive profiling of HLA-bound peptides, yet detection remains challenging due to their non-tryptic nature, variable lengths, and lack of basic residues, which limit ionisation and fragmentation efficiency. To address these limitations, we investigated ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD072997 | Pride
Immunopeptidomics Dmso Supercharging 
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