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ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD027425 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-09-12 | PXD027279 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
ProteomicsGlycoproteomics profiling of recombinant SARS-CoV-2 stabilized Spike construct
N-linked glycans of recombinant SARS-CoV-2 Spike protein with stabilizing mutations were profiled by LC-MS/MS.
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2021-07-28 | PXD025554 | Pride
Sars-cov-2 Glycoproteomics Covid-19 
ProteomicsProteomics,N-glycoproteomics and Phosphoproteomics of SARS-Cov-2 Infected Calu-3 Cells
We present an multiple proteomics study of SARS-Cov-2 infection to comprehensively decipher the changes in host cells in response to viral infection, including global proteomics, N-glycoproteomics and phosphoproteomics.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037097 | Pride
Sars-cov-2 Calu-3 
ProteomicsSite-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins using High-Resolution Mass Spectrometry
The global pandemic of severe acute pneumonia syndrome (COVID-19) caused by SARS-CoV-2 urgently calls for prevention and intervention strategies. The densely glycosylated spike (S) protein highly exposed on the viral surface is a determinant for virus binding and invasion into host cells as well as ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-05 | PXD018506 | Pride
Sars-cov-2  spike protein  n-glycosylation  mass spectrometry 
ProteomicsSARS-CoV-2 QTQTN motif mutant PTM-peptide mapping
3 strains of SARS-CoV-2 were created to the function of the QTQTN motif adjacent to the Furin cleavage site on Spike protein: WT (QTQTN), Mutant 1 (QTQVN), Mutant 2 (QVQVN).
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2022-07-20 | PXD034332 | Pride
Sars-cov-2 glycoproteomics 
ProteomicsN and O glycosylation of the SARS-CoV-2 spike protein
Glycoproteomics analysis of N and O glycosylation of the SARS-CoV-2 spike protein using modulated collision energy and cyclicIMS
ORGANISM(S): Cellular Organisms 
2021-11-21 | PXD022657 | JPOST Repository
ProteomicsRevealing the effect of SARS-CoV-2 spike stabilisation on receptor binding dynamics with single molecule mass photometry
Here we show using mass photometry how proline substitutions, commonly used for SARS-CoV-2 spike stabilisation and vaccine design, directly impedes ACE2 receptor interactions via dynamics of open and closed states. Conformational changes and ACE2 binding were influenced by spike variant and temperat...
ORGANISM(S): Homo sapiens (Human) 
2023-06-28 | PXD036289 | Pride
Sars-cov-2 Glycomics Spike Glycoproteomics Mass photometry Ace2 
ProteomicsStructural Dynamic Impacts of Mosaic SARS-CoV-2 Spike Heterotrimer
Polyvalent vaccines are being widely investigated for their broadening immune responses against rapidly mutating pathogens. In response to the emergence of highly infectious SARS-CoV-2 variants of concern, bivalent mRNA vaccines, which encode the original Hu-1 variant and Omicron variant, have demon...
ORGANISM(S): Homo sapiens (Human) 
2025-09-17 | PXD060785 | Pride
Spike glycoprotein Hdx-ms Sars-cov-2 Antigen display 
ProteomicsRe-analysis of glycoproteomics data with Glyco-Decipher
Reanalysis of submissions PXD005411, PXD005413, PXD005412, PXD005553, PXD005555, PXD005565 and PXD019937 using Glyco-Decipher. Identification results of peptide-spectrum matches supporting Glyco-Decipher manuscript (Glyco-Decipher: glycan database-independent peptide matching enables discovery of ne...
ORGANISM(S): Mus musculus (Mouse) Saccharomyces cerevisiae (Baker's yeast) 
2022-03-04 | PXD031032 | Pride
Glycoproteomics  glycopeptide  reanalysis  glycosylation  n-glycosylation 
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