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MetabolomicsIntegrated multi-omics analysis reveals insulin-induced metabolic adaptation of Hu sheep skeletal muscle satellite cells: inhibiting proliferation while promoting myogenesis

Background Skeletal muscle satellite cells (SMSCs) possess bidirectional differentiation potential and are potential targets for improving meat quality in animal production. However, SMSCs do not spontaneously undergo adipogenesis, and insulin is a classic...

2026-10-27 | MTBLS15376 | MetaboLights
TranscriptomicsFibronectin regulates Wnt7a signaling and satellite cell expansion
The influence of the extracellular matrix (ECM) within the stem cell niche remains poorly understood. We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a coreceptor complex in satellite cells and that binding of the ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a t...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59272 | biostudies-arrayexpress
MetabolomicsHyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
Premature infants require oxygen supplementation to survive, but excess oxygen causes retinovascular growth suppression that underlies the leading cause of infant blindness known as retinopathy of prematurity (ROP). We analyzed changes in intermediary metabolism during hyperoxia in human retinal end...
2020-03-12 | MTBLS1228 | MetaboLights
TranscriptomicsRNA-seq from myogenic satellite cells from a translational porcine model for Duchenne muscular dystrophy, heterozygous female carriers, and their healthy wild-type counterpart
Satellite cells (SCs), the stem cell population of skeletal muscle, are crucial for growth and regeneration, and their dysfunction is increasingly recognized as a contributing factor to Duchenne muscular dystrophy (DMD). DMD is a severe, X-linked disorder caused by DMD gene mutations, leading to lo...
ORGANISM(S): Sus scrofa 
2025-12-11 | E-MTAB-16179 | biostudies-arrayexpress
TranscriptomicsA Pitx2-miRNA pathway modulates cell proliferation in myoblasts and skeletal-muscle satellite cells and promotes their commitment to a myogenic cell fate.
The acquisition of a proliferating cell status from a quiescent state as well as the shift between proliferation and differentiation are key developmental steps in skeletal-muscle stem cells (satellite cells) to provide proper muscle regeneration. However, how satellite-cell proliferation is regulat...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-53943 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse satellite cells isolated from skeletal muscle
(Abstract of publication submitted currently) To clarify molecular regulation of satellite cells, we performed genome-wide gene expression analysis of quiescent satellite cells isolated from mouse skeletal muscle by flow cytometry. We identified 53 novel quiescent satellite cell-specific genes whos...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3483 | biostudies-arrayexpress
ProteomicsProteome analysis of satellite cells from DMD and WT pigs
Recent studies on the contribution of satellite cells (SC) to Duchenne muscular dystrophy (DMD) documented altered division capacities and impaired regeneration potential of SC in muscle tissue of DMD patients and animal models. Hence, it is crucial to unravel if SC-intrinsic effects trigger these d...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-06-30 | PXD059983 | Pride
Dystrophin Satellite cells Duchenne muscular dystrophy 
TranscriptomicsExpression data of satellite cells through muscle injury time course
Satellite cells are resident skeletal muscle stem cells responsible for muscle maintenance and repair. In resting muscle, satellite cells are maintained in a quiescent state. Satellite cell activation induces the myogenic commitment factor, MyoD, and cell cycle entry to facilitate transition to a ...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-38870 | biostudies-arrayexpress
TranscriptomicsExpression data during plantaris muscle hypertrophy with/without satellite cells induced by synergist ablation in young adult Pax7-DTA mice
Global gene expression patterns were determined from microarray results from sham surgery or following 1 week of plantaris muscle hypertrophy induced by synergist ablation in young adult Pax7-DTA mice (4 months). Vehicle treated mice have their full complement of satellite cells; tamoxifen treated m...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-52597 | biostudies-arrayexpress
ProteomicsIdentification of alpha-satellite RNA interacting proteins
We set out to identify proteins that bind alpha-satellite ncRNAs in HCT-116 and SW-480 colorectal cancer human cell lines. We performed RNA pulldown followed by mass spectrometry identification of the associated proteins. Among the identified proteins, we observed a statistical overrepresenttion of ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD024582 | Pride
Rna pulldown Ncrna Alpha satellite 
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