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ProteomicsAssessing Target Specificity of the Small Molecule Inhibitor Marimastat to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling
New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of medically significant venom toxins in vivo and in vitro. The developmen...
ORGANISM(S): Crotalus atrox 
2024-06-22 | PXD046399 | Pride
Thermal proteome profiling Snake venom Metalloprotease 
UnknownEffect of Dietary Chestnut or Quebracho Tannin Supplementation on Microbial Community and Fatty Acid Profile in the Rumen of Dairy Ewes.
Not available
S-EPMC5804114 | biostudies-literature
UnknownStreptococcus pneumoniae GAPN is a key metabolic player necessary for host infection.
Not available
S-EPMC11633051 | biostudies-literature
UnknownStreptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes.
Not available
S-EPMC12745498 | biostudies-literature
ProteomicsTargeting of CGRP signaling reverses maladaptive neurogenic immunosuppression in head and neck squamous cell carcinoma
Neurogenic inflammation is one component that sculpts the immune milieu of solid tumors. However, it remains unclear how the sensory-neuroimmune axis shapes the immune microenvironment in cold tumors to bolster treatment resistance. Using orthotopic head and neck squamous cell carcinoma (HNSCC) mode...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD081773 | Pride
Cgrp signaling Head and neck squamous cell carcinoma 
ProteomicsImpact of the identification strategy on reproducibility of DDA and DIA results
Study of the impact of the identification strategy used for DDA and DIA results
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-17 | MSV000081719 | MassIVE
UnknownLong-term life expectancy in severe traumatic brain injury: a systematic review.
Not available
S-EPMC11561474 | biostudies-literature
ProteomicsA developmental shift in venom toxin expression underpins a major prey switch in Australian Brown Snakes
Many animals undergo morphological, physiological, and behavioral changes over the course of their life history. It has been proposed that some of these developmental changes evolve in concert with shifts in ecology, but there are relatively few clear examples, and identifying the underlying molecul...
ORGANISM(S): Pseudonaja modesta Pseudonaja textilis Pseudonaja aspidorhyncha 
2026-04-13 | PXD063001 | Pride
UnknownLife expectancy and long-term survival after traumatic spinal cord injury: a systematic review.
Not available
S-EPMC11559252 | biostudies-literature
ProteomicsPP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA pol II transcription termination
The restrictor, ZC3H4/WDR82, terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitate with PP1 phosphatase and its nuclear targeting subunit, PNUTS, which binds to WDR82. AlphaFold predicts a complex of PP1/...
ORGANISM(S): Homo sapiens (Human) 
2025-04-06 | PXD061598 | Pride
Pp1 phosphatase Ctd dephosphorylation Zc3h4 Pol ii ctd ser5 phosphorylation Restrictor Wdr82 Transcription termination Transcription elongation 
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