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ProteomicsMinute-scale proteomics with Scanning SWATH and high-flow chromatography
Great advances have been made to quantify proteomes at depth and high precision. However, the inherent complexity of the proteome still creates huge challenges to deal with large sample series and longitudinal experiments. Here we report a data-independent acquisition (DIA) method, Scanning SWATH, a...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-03-02 | PXD023613 | Pride
High-throughput High-flow chromatography Drug screen Scanning swath Data-independent acquisition 
UnknownUltra-fast proteomics with Scanning SWATH.
Not available
S-EPMC7611254 | biostudies-literature
ProteomicsPerformance Characteristics of Zeno Trap Scanning DIA for Sensitive and Quantitative Proteomics at High Throughput
Proteomic experiments, particularly those addressing dynamic proteome properties, time series, or genetic diversity, require the analysis of large sample numbers. Despite significant advancements in proteomic technologies in recent years, further improvements are needed to accelerate measurement and...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2026-01-19 | PXD063462 | Pride
ProteomicsDifferential gene expression of cells located in the top and bottom of yeast colonies
Saccharomyces cerevisiae colonies were grown on synthetic minimal media containing 1% glucose. The top layer of cells was scraped off using a custom plastic guide and a cell scraper. The remaining bottom layer of cells was then washed off with water and proteomics samples were prepared from both lay...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-13 | PXD033395 | Pride
Dia Swath Colony Yeast 
ProteomicsCharacterization of plasma proteins of HIV/AIDS patients underfirst line anti-retroviral therapy
The retrospective cohort study was focused on the first line ART patients who were enrolled in the antiretroviral therapy center, Sarojini Naidu Medical College, Agra, India from December 2009 to November 2016. The main criteria for inclusion was based on the immunological marker, i.e. CD4+ count (<...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD016843 | Pride
Hiv Aids Swath-ms Art Human plasma proteins 
ProteomicsDifferential gene expression of yeast colonies in response to lysine
Saccharomyces cerevisiae colonies were grown for 2 days on synthetic minimal media with 1% glucose, with and without 400uM lysine (5 colonies/biological replicates each). Whole colonies were then used for proteome profiling by SWATH-MS for differential gene expression analysis. A number of genes wer...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-13 | PXD030702 | Pride
Dia Swath Gene expression Lysine Colony Saccharomyces cerevisiae 
ProteomicsSWATH-MS analysis of 3-hydroxy-3-methylglutaryl-CoA synthase specific inhibitor (F-244)-treated Arabidopsis
3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the second enzyme in the mevalonate pathway. F-244 is the specific inhibitor of HMGS. F-244 treatment caused reduced primary root growth. SWATH-MS quantitative proteomics analysis was carried out to identify differential expressed proteins in F-244-t...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-10-01 | PXD009776 | Pride
Arabidopsis thaliana F-244 Proteomics Swath Hmgs 
ProteomicsSWATH-MS analysis of transgenic tobacco overexpressing 3-hydroxy-3-methylglutaryl-CoA synthase
3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the second enzyme in the mevalonate pathway. While the recombinant Brassica juncea HMGS1 (BjHMGS1) mutant S359A displayed 10-fold higher enzyme activity than wild-type (wt) BjHMGS1, transgenic tobacco overexpressing S359A (OE-S359A) exhibited greater...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2021-01-04 | PXD006869 | Pride
Swath Proteomics analysis Hmgs Nicotiana tabacum 
MetabolomicsUntargeted In Silico Compound Classification - A Novel Metabolomics Method to Assess the Chemodiversity in Bryophytes

In plant ecology, biochemical analyses of bryophytes and vascular plants are often conducted on dried herbarium specimen as species typically grow in distant and inaccessible locations. Here, we present an automated in silico compound classification framework to annotate metabolites using an unta...

2026-01-30 | MTBLS851 | MetaboLights
ProteomicsScanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
A prevalent view in treating age-dependent disorders including Alzheimer’s disease (AD) is that the underlying amyloid plaque pathology must be targeted for cognitive improvements. In contrast, we report here that repeated scanning ultrasound (SUS) treatment at 1 MHz frequency can ameliorate memory ...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD050248 | Pride
Blood-brain barrer Amyloid-β Quantitative proteomics Alzheimer's disease 
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