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ProteomicsCathepsin B interstitial fluid proteome of murine breast cancers
MS-based proteomics study of the interstitial fluid of breast cancer of mice lacking or overexpressing cathepsin B
ORGANISM(S): Mus musculus (Mouse) 
2016-03-31 | PXD002585 | Pride
Lc-msms Interstitial fluid Q exactive plus Mouse 
TranscriptomicsIL13_0-12h_RAIA_et_al
Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share a frequent constitutive activation of Janus-activated kinase (JAK) / signal transducer and activator of transcription (STAT) signaling pathway. Due to complex non-linear relations within the pathway, key dynamic pr...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-23591 | biostudies-arrayexpress
ProteomicsDetermination of the specificity profiling of native and synthetic cardosin B using proteomic identification of protease cleavage sites (PICS)
We performed an analysis of the substrate specificity preferences of native and synthetic cardosin B using the Proteomic Identification of protease Cleavage Sites methodology and some differences regarding preference and stringency of the subsite binding pockets were observed. Results clearly sugges...
ORGANISM(S): Homo sapiens (Human) 
2018-05-04 | PXD006329 | Pride
Cardosin Pics 
ProteomicsStructural determinants of specificity and antagonistic Ca2+ and Zn2+ regulation of peptidase activity in human KLK8/neuropsin
Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and hippocampus, where it regulates memory formation by synaptic remodeling. Recombinantly expressed KLK8 revealed a good accordance two substrate profiling methods: positional scanning with fluorogenic tetrapep...
ORGANISM(S): Escherichia coli 
2018-10-17 | PXD006884 | Pride
Protease Peptide library 
ProteomicsThe papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B
The tobacco-related plant Nicotiana benthamiana is gaining interest as a versatile host for the production of monoclonal antibodies and other protein therapeutics. However, the susceptibility of plant-derived recombinant proteins to endogenous proteolytic enzymes limits their use as biopharmaceutica...
ORGANISM(S): Escherichia coli 
2021-12-01 | PXD005542 | Pride
Protease Specificity Proteome-derived peptide library 
ProteomicsCathepsin B and Cathepsin Z tumor secretome of murine breast cancers
MS-based proteomics study of the cancer secretome and tumor interstitial fluid of tumor cell/macrophage co-cultures and breast tumors in cells and mice lacking both cathepsin B and cathepsin Z
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015209 | Pride
Tumor interstitial fluid Ccm Mouse Secretome 
UnknownInduction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.
Not available
S-EPMC5971225 | biostudies-literature
UnknownCAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation.
Not available
S-EPMC7604878 | biostudies-literature
UnknownDeletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.
Not available
S-EPMC3591655 | biostudies-literature
ModelsRaia2011 - IL13 L1236
This is the model of IL13 induced signalling in L1236 cells described in the article: Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows Prediction of Therapeutic Targets. Raia V, Schillin...
2024-09-02 | BIOMD0000000314 | BioModels
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