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UnknownIdentification of O-linked N-acetylglucosamine (O-GlcNAc)-modified osteoblast proteins by electron transfer dissociation tandem mass spectrometry reveals proteins critical for bone formation.
Not available
S-EPMC3617341 | biostudies-literature
ProteomicsStructural determinants of specificity and antagonistic Ca2+ and Zn2+ regulation of peptidase activity in human KLK8/neuropsin
Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and hippocampus, where it regulates memory formation by synaptic remodeling. Recombinantly expressed KLK8 revealed a good accordance two substrate profiling methods: positional scanning with fluorogenic tetrapep...
ORGANISM(S): Escherichia coli 
2018-10-17 | PXD006884 | Pride
Protease Peptide library 
UnknownSex-dependent behavioral functions of the Purkinje cell-specific Gαi/o binding protein, Pcp2(L7).
Not available
S-EPMC5438593 | biostudies-literature
ProteomicsProteome Profiling of Renal Cancer Tumor Tissue and Non-Affected Renal Tissue in Patients with Von Hippel-Lindau Disease Highlights Differential Regulation of Xaa-Pro Aminopeptidases-1 and -2 (XPNPEP-1 and -2)
Patients with loss-of-function mutations of the von Hippel Lindau gene (“VHL-patients”) often develop clear cell renal cell carcinoma (ccRCC). Using archived, formalin-fixed, paraffin-embedded (FFPE) samples and a cohort of eight cases, we sought to determine global proteome alterations that disting...
ORGANISM(S): Homo sapiens (Human) 
2017-08-28 | PXD005710 | Pride
Von-hippel-lindau Exoproteases 
ProteomicsProteomic Distinction of Renal Oncocytomas and Eosinophilic Chromophobe Renal Cell Carcinomas
Background Renal oncocytomas (ROs) are benign epithelial tumors of the kidney that may progress into malignant chromophobe renal cell carcinoma (chRCCs), with the latter constituting 5 – 7 % of renal neoplasias. ROs and chRCCs show pronounced molecular and histological similarities, which renders th...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD009300 | Pride
Paraffin embedment proteomics immunohistochemistry Renal cell tumors formalin-fixation 
ProteomicsA human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
The human genome consists of considerable portions derived from retroviruses typically inherited already for millions of years. So-called human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERV sequences exist. The HERV-K(HML-2) group includes evolutionaril...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD010159 | Pride
Protease N-terminomics 
UnknownNeuron-targeted caveolin-1 improves neuromuscular function and extends survival in SOD1G93A mice.
Not available
S-EPMC6529340 | biostudies-literature
ProteomicsThe bacterial porin OmpA is an inhibitor of Bak-activation at mitochondria and blocks apoptosis of human cells infected with Chlamydia trachomatis
Many infectious agents have the need to inhibit host apoptosis, and various strategies are known. Chlamydia trachomatis is an obligate intracellular bacterium replicating in a vacuole in the human cytosol. Chlamydia-infected human cells are strongly protected against apoptosis. We here mapped this a...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD011848 | Pride
Ompa Mitochondria Chlamydia trachomatis Apoptosis Bcl-2 
ProteomicsSpecificity profiling of LysargiNase in comparison to trypsin
Protease cleavage site preferences of LysargiNase (former name: ulilysin) and trypsin were tested using proteome-derived peptide libraries (Schilling et al Nature Protocols 2011)
ORGANISM(S): Escherichia coli 
2014-12-16 | PXD001122 | Pride
Protease Pics Sequence specificity 
Proteomicsyeast membrane proteomics using Leu3 labelling
The yeast signal peptide peptidase homologue Ypf1 functionally interacts with the ER-associated degradation (ERAD) factors Dfm1 and Doa10 to control the abundance of the zinc transporter Zrt1. Here we report that Ctr1 is another substrate for this degradation mechanism with deletion of Ypf1 leading ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-04-12 | PXD003052 | Pride
Proteomics Erad Leu3 labelling Yeast Membrane 
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