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ProteomicsMulti-laboratory analysis of sample stability for proteomics following non-cooled international transport
As international collaborative research grows there is increasing desire to transport specimens around the globe. Transporting biological samples such as cells or tissues is complicated by the need to maintain integrity and minimise modification and degradation, but this is economically costly as th...
ORGANISM(S): Homo sapiens (Human) 
2018-03-02 | PXD008160 | Pride
Lc-ms Proteomics Peptides Multi-laboratory Stability 
ProteomicsDirect 3D sampling of the embryonic mouse head: Layer-wise nanosecond infrared laser (NIRL) ablation from scalp to cortex for spatially resolved proteomics
Common workflows in bottom-up proteomics require homogenization of tissue samples giving to get access to the biomole-cules within the cells. The homogenized tissue samples often contain many different cell types, thereby representing an average of the natural proteome composition and rare cell type...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043011 | Pride
Nirl ablation Spatial proteomics Tissue sampling Bottom-up proteomics 
ProteomicsSpatial proteomics of T-cell infiltrates in melanoma reveals differential regulation of TOR signaling
The tumor microenvironment determines the clinical response of patients to therapeutic immune checkpoint inhibition (ICI), but a comprehensive understanding of the underlying immune-regulatory proteome is still lacking. To better understand and assess targetable promising biological processes that s...
ORGANISM(S): Homo sapiens (Human) 
2025-03-04 | PXD035502 | Pride
Spatial proteomics T cell infiltrate Melanoma Immune checkpoint inhibition Lc-ms/ms 
ProteomicsHypoxia-induced adaptations of N-glycomes and proteomes in breast cancer cells and their secreted extracellular vesicles
The hypoxic tumor microenvironment significantly impacts cellular behavior and intercellular communication, with extracellular vesicles (EVs) playing a crucial in promoting angiogenesis, metastasis, and host immunosuppression. Aberrant surface N-glycan expression in EVs is closely associated with c...
ORGANISM(S): Homo sapiens (Human) 
2024-11-07 | PXD053696 | Pride
N-glycomics Proteomics N-glycosylation Hypoxia Extracellular vesicles 
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