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GenomicsCharacterization of SOC1’s central role in flowering by the identification of its upstream and downstream regulators
The transition from vegetative to reproductive development is one of the most important phase changes in the plant life cycle. This step is controlled by various environmental signals that are integrated at the molecular level by so-called floral integrators. One such floral integrator in Arabidopsi...
ORGANISM(S): Arabidopsis thaliana 
2013-04-09 | E-GEOD-45846 | biostudies-arrayexpress
TranscriptomicsTranscription analysis of E. coli processed at persistent and decreasing glucose limitation in a fed-batch cultivation
A time series of whole-genome transcription profiling of E. coli K-12 W3110 was performed to study the dynamic physiological response of E. coli K-12 W3110 to limited carbon conditions. cDNA from eight time intervals after glucose limitation, representing different stages of glucose depletion, along...
ORGANISM(S): Escherichia coli W3110 
2010-05-19 | E-GEOD-10307 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 80 Arabidopsis tissues/cells (AtGenExpress data) see also E-TABM-17 for a re-annotated set with CEL files for download
The activity of genes and their encoded products can be regulated in several ways, but transcription is the primary level, since all other modes of regulation (RNA splicing, RNA and protein stability, etc.) are dependent on a gene being transcribed in the first place. The importance of transcription...
ORGANISM(S): Arabidopsis thaliana 
2022-11-20 | E-AFMX-9 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila embryos at stages 11 and 12 to identify genes downstream of Hox
Identification of Hox gene downstream genes at embryonic stages 11 and 12

Functional diversification of body parts is dependent on the formation of specialized structures along the various body axes. In animals, region-specific morphogenesis along the anterior-posterior axis is controlled by ...
ORGANISM(S): Drosophila melanogaster 
2008-04-09 | E-MEXP-879 | biostudies-arrayexpress
ProteomicsPro-inflammatory activity following demyelinating injury is required for phagocytic function and oligodendrocyte formation
Remyelination can occur naturally in demyelinating lesions, but often fails in human demyelinating diseases such as multiple sclerosis (MS). The function of the innate immune system is essential for the regenerative response, but how exactly microglia and macrophages clear myelin debris after injury...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD014625 | Pride
Myd88 Myelin Mouse Microglia 
ProteomicsPlasma proteomics of BACE1, 2, and double KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed glycoprotein enrichment and subsequent...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041577 | Pride
Bace2 Glycocapture Beta secretase Plasma 
ProteomicsPlasma proteomics of BACE2 KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify subst...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041579 | Pride
Bace2 Beta secretase Plasma Mouse 
ProteomicsPlasma proteomics of mice treated with BACE inhibitors
The Beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. To discover potential BAC2 substrates in plasma, mice wer...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD042669 | Pride
Bace Plasma Mus musculus 
TranscriptomicsGenome-wide maps of chromatin changes uppon contextual fear conditioning in mice (RNA-seq)
The ability to form memories is a prerequisite for an organism’s behavioural adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-74966 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin changes uppon contextual fear conditioning in mice (meDIP-seq)
The ability to form memories is a prerequisite for an organism’s behavioural adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-74965 | biostudies-arrayexpress
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