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MetabolomicsThe downside of metabolic diversity: Postingestive rearrangements by specialized insects
Deploying toxins in complex mixtures is thought to be advantageous and is observed during antagonistic interactions in nature. Toxin mixtures are widely utilized in medicine and pest control, as they are thought to slow the evolution of detoxification counterresponses in the targeted organisms. Here...
2022-12-04 | MTBLS3676 | MetaboLights
TranscriptomicsIncreased expression of Bcl11b in human transformed T cell lines leads to chemoresistance accompanied by G1 accumulation.
ABSTRACT Background: The expression of BCL11B has been reported in normal and transformed cells derived from T-lymphocytes, neurons, keratinocytes and recently in a subset of squamous cell carcinomas. Despite the rapidly accumulating knowledge concerning Bcl11b biology, the contribution of this prot...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-21382 | biostudies-arrayexpress
ProteomicsBCL11B_AP-MS - The N-terminal CCHC zinc finger motif mediates homodimerization of the transcription factor BCL11B
This study investigates whether the N-terminal CCHC zinc finger motif is necessary and sufficient for the formation of BCL11B dimers, using fluorescence microscopy and Förster resonance energy transfer-assisted fluorescence-activated cell sorting (FACSFRET). The role of the CCHC motif in homodimer a...
ORGANISM(S): Homo sapiens (Human) 
2018-01-12 | PXD008606 | Pride
Srm Co-immuno precipitation Ap-ms Ppin Lc-ms/ms 
UnknownCytopathicity of Chlamydia is largely reproduced by expression of a single chlamydial protease.
Not available
S-EPMC2447887 | biostudies-literature
UnknownUnbiased identification of novel subclinical imaging biomarkers using unsupervised deep learning.
Not available
S-EPMC7395081 | biostudies-literature
UnknownReduction of permanent pacemaker implantation by using the cusp overlap technique in transcatheter aortic valve replacement: a meta-analysis.
Not available
S-EPMC10160159 | biostudies-literature
ProteomicsProtein aggregation is a consequence of the dormancy-inducing membrane toxin TisB in Escherichia coli
Protein aggregates occur in all living cells due to misfolding of proteins. In bacteria, protein aggregation is associated with cellular inactivity, which is related to dormancy and tolerance to stressful conditions, including the exposure to antibiotics. In Escherichia coli, the membrane toxin TisB...
ORGANISM(S): Escherichia coli 
2024-10-04 | PXD049478 | Pride
Toxin-antitoxin system Antibiotics Dormancy Protein aggregation Type i toxin 
TranscriptomicsTranscription profiling of glucocorticoid resistant and sensitive acute lymphoblastic leukemia cell lines
Gene expression data of glucocorticoid resistant and sensitive acute lymphoblastic leukemia cell lines for the article: Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells Glucocortic...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-22152 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of non-leukemic individuals before and during in-vivo glucocorticoid treatment
Article title: Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells. Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and constitute a central component in ...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-22779 | biostudies-arrayexpress
TranscriptomicsExpression data of inducible stable cell lines overexpressing Ero1alpha WT and Ero1alpha C104A/C131A
The overall cellular response to oxidative stress generated by Ero1M-NM-1 in the lumen of the mammalian endoplasmic reticulum (ER) is poorly characterized. Here, we investigate the effects of overexpressing a hyperactive mutant (C104A/C131A) of Ero1M-NM-1. Using microarray analysis, we demonstrate t...
ORGANISM(S): Homo sapiens 
2012-09-07 | E-GEOD-40601 | biostudies-arrayexpress
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