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TranscriptomicsTranscription profiling of wild type and Clcn7-/- mouse hippocampus at p14
Comparison of expression levels between wild type and Clcn7-/- mouse hippocampus at p14. 3 wild type and 3 mutant mice were studied.
ORGANISM(S): Mus musculus 
2005-03-01 | E-MEXP-242 | biostudies-arrayexpress
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019755 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion Refed mice 
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019757 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion 
TranscriptomicsMechanisms and rescue strategies of Calcineurin inhibitor mediated tolerance abrogation
To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs IS. But IS such as calcineurin inhibitors CNI can interfere with tolerance induction. We investigated the effect of an additional CNI treatment on anti-CD4 mAb-induced tolerance induction upon rat ...
ORGANISM(S): Rattus norvegicus 
2013-09-01 | E-GEOD-40454 | biostudies-arrayexpress
TranscriptomicsMALT1 protease activity controls the expression of inflammatory genes in keratinocytes upon Zymosan stimulation
The protease activity of the paracaspase MALT1 plays an important role in antigen receptor-mediated lymphocyte activation by controlling the activity of the transcription factor NF-kB and is thus essential for the expression of inflammatory target genes. MALT1 is not only present in cells of the hem...
ORGANISM(S): Homo sapiens 
2015-10-24 | E-GEOD-74297 | biostudies-arrayexpress
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