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TranscriptomicsGene expression in Delta Sub1 with and without 4NQ0
Microarrays analysis was undertaken to compare mRNA levels in exponentially growing wild-type and sub1Δ cells, or after 1 h treatment with 4NQO. After spot quantification and normalization, only few genes were found to be differentially expressed when the two strains were exponentially grown in rich...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-01 | E-GEOD-11124 | biostudies-arrayexpress
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019755 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion Refed mice 
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019757 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion 
ProteomicsLC-MSMS on mouse retina to investigate photoreceptor degeneration
Intraocular anti-VEGFA injections are frequently used to counteract neovascularization in diseases such as the neovascular (wet) form of age-related macular degeneration (AMD) or proliferative diabetic retinopathy. However, in the clinical context, patients with atrophic (dry) and wet AMD in the sam...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD066263 | Pride
Vegfr2 deletion Photoreceptor Lc-msms 
ProteomicsLKB1 is a suppressor of amino acid-driven gluconeogenesis in the liver
Excessive hepatic glucose production is a major contributor to the hyperglycemia observed in Type 2 diabetes mellitus. It is widely accepted that it is due to an increase in hepatic gluconeogenesis. While much attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes,...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD013478 | Pride
Gluconeogenesis Maxquant Mus musculus Sarcopenia Liver Q-exactive Label-free Amino acids Lkb1 Insulin 
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