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TranscriptomicsGene expression profile of cell lines 2106T, H1975 and MeWo after knockdown of PAEP.
Gene expression profile was analyzed after knockdown of PAEP in lung cancer cell lines 2106T and H1975 as well as in skin cancer cell line MeWo. The aim of the study was to investigate the role of PAEP and its protein product glycodelin in lung cancer cell lines. Cells were treated with a control si...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-60888 | biostudies-arrayexpress
GenomicsMINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells
Despite the established role of the transcription factor MYC in cancer, little is known about the involvement of lncRNAs in mediating MYC’s function. Here we have intersected RNA-sequencing data from MYC-inducible cell lines, from a cohort of 91 mature B-cell lymphomas and from sorted germinal-cente...
EGAS00001001199 | EGA
ProteomicsPrm2 deficiency triggers a Reactive Oxygen Species (ROS)-mediated destruction cascade during epididymal sperm maturation in mice
MTD project_description Protamines are testis-specific proteins, which replace the majority of histones during spermiogenesis. This results in a hypercondensation of the sperm DNA, finally causing a conformational change from a nucleosomal chromatin structure into a mainly toroid like structure. Thi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-29 | PXD018843 | Pride
Epididymal sperm Mouse Lc-ms Protamine2 deficient Male Proteome 
ProteomicsZc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to other components of the m6A machinery
N6-methyladenosine (m6A) is an abundant RNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly understood. Here we identified Flacc/Zc3h13 as a nove...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2018-12-20 | PXD008111 | Pride
Rna modifications Flacc Methyltransferase complex M6a Sex determination Zc3h13 
UnknownManagement of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.
Not available
S-EPMC6481621 | biostudies-literature
Genomicsena-DATASET-DKFZ-IBIOS-16-07-2015-15:45:02:488-51 - samples
Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long non-coding RNAs (lncRNAs), on the way MYC is able to influence cellular transcriptome. To this aim we have intersected RNA-sequencing data f...
EGAD00001001441 | EGA
GenomicsSARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
The SARS‐CoV‐2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID‐19 pathogenesis, especially host factors facilitating virus infection and replication. SARS‐CoV‐2 was reported to enter cells via binding to...
EGAS00001004419 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
Genomicsena-DATASET-DKFZ-29-05-2020-15:56:12:496-205 - samples
ALI culture bronchial cells and alveolar lung surgical resection scRNA-Seq
EGAD00001006185 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsDAC for patient-derived cell line samples
Data Access Committee EGAC00001000594
EGAC00001000594 | EGA
UnknownTrends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021.
Not available
S-EPMC11330450 | biostudies-literature
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