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TranscriptomicsIdentification of re-capping substrates for the cytoplasmic capping enzyme complex
The analysis of capped RNAs by massively parallel sequencing has identified a large number of previously unknown transcripts, some of which are small RNAs and others are 5M-bM-^@M-^Y truncated forms of RefSeq genes. The latter may be generated by endonuclease cleavage or by stalling of Xrn1 at defi...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-36729 | biostudies-arrayexpress
TranscriptomicsProbing Xist RNA structure in cells using Targeted Structure-Seq
The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation in mammalian cells. Models for how Xist and other lncRNAs function depend on thermodynamically stable secondary and higher-order structures that RNAs can form in the context of a cell. Probing accessible RNA bas...
ORGANISM(S): Mus musculus 
2016-02-09 | E-GEOD-67667 | biostudies-arrayexpress
ProteomicsCytoplasmic capping enzyme interactome
Formaldehyde crosslinking and Proximity-dependent biotinylation methods were applied to study the cytoplasmic capping enzyme interactome via 1D-LC-MS/MS. The raw data were searched against Uniprot human database modified to contain our designed protein sequences using the Thermo Proteome Discoverer ...
ORGANISM(S): Homo Sapiens (human) 
2018-08-30 | PXD010368 | JPOST Repository
UnknownInhibition of cytoplasmic cap methylation identifies 5' TOP mRNAs as recapping targets and reveals recapping sites downstream of native 5' ends.
Not available
S-EPMC7144985 | biostudies-literature
TranscriptomicsRNA-microarray analysis of PLB-985 cells cultured with or without interferon-gamma under both conditions that induce or do not induce cell differentiation
Interferon-gamma (IFN-gamma) is approved as a drug to treat chronic granulomatous disease and osteopetrosis and is also used in hyperimmunoglobulin E syndromes. These primary immunodeficiencies involve defects in neutrophils/polymorphonuclear cells. Neutrophils mature in the bone marrow and then e...
ORGANISM(S): Homo sapiens 
2017-08-31 | E-MTAB-5690 | biostudies-arrayexpress
UnknownPolypill with or without Aspirin in Persons without Cardiovascular Disease.
Not available
S-EPMC7116860 | biostudies-literature
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