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ProteomicsInhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNAcylation of DNMT1 from high glucose environment le...
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD043031 | Pride
Metabolism O-glcnacylation Epigenetics Hyperglycemia 
TranscriptomicsTranscription profiling by array of human CD4 positive cells after activation with antiCD3/28 beads
The positioning of nucleosomes with respect to DNA plays an important role in regulating transcription. However, nucleosome mapping has been performed for only limited genomic regions in humans. We have generated genome-wide maps of nucleosome positions in both resting and activated human CD4+ T c...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-10437 | biostudies-arrayexpress
GenomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption
Histone modifications associated with gene silencing typically mark large contiguous regions of the genome forming repressive chromatin domain structures. Since the repressive domains exist in close proximity to active regions, maintenance of domain structure is critically important. This study show...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-56053 | biostudies-arrayexpress
TranscriptomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption [RNA-Seq]
Alterations in chromatin modifications, including DNA methylation and histone modification patterns, have been characterized under exposure of several environmental pollutants, including nickel. As with other carcinogenic metals, the mutagenic potential of nickel compounds is low and is not well cor...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-56052 | biostudies-arrayexpress
GenomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption [ChIP-Seq]
Alterations in chromatin modifications, including DNA methylation and histone modification patterns, have been characterized under exposure of several environmental pollutants, including nickel. As with other carcinogenic metals, the mutagenic potential of nickel compounds is low and is not well cor...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-56051 | biostudies-arrayexpress
GenomicsGenome-wide mapping of HATs and HDACs in human CD4+ T cells
Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs ...
ORGANISM(S): Homo sapiens 
2009-08-20 | E-GEOD-15735 | biostudies-arrayexpress
TranscriptomicsMonovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis
We use male gonads isolated from a Drosophila strain that allows us to obtain enough cells at their primitive status as the starting material to study the endogenous chromatin structure of undifferentiated cells using ChIP-seq. We integrate the ChIP-seq data with RNA-seq data that measures the trans...
ORGANISM(S): Drosophila melanogaster 
2010-04-16 | E-GEOD-19325 | biostudies-arrayexpress
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