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ProteomicsActl7b-deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis
Actin-related proteins (Arp) are classified according to their similarity to actin and are involved in diverse cellular processes. ACTL7B is a testis-specific Arp and highly conserved in rodents and primates. ACTL7B is specifically expressed in round and elongating spermatids during spermiogenesis. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-19 | PXD038920 | Pride
Actl7b Lc8 light chains Actin-related proteins Mouse Infertility Spermatogenesis 
ProteomicsPrm2 deficiency triggers a Reactive Oxygen Species (ROS)-mediated destruction cascade during epididymal sperm maturation in mice
MTD project_description Protamines are testis-specific proteins, which replace the majority of histones during spermiogenesis. This results in a hypercondensation of the sperm DNA, finally causing a conformational change from a nucleosomal chromatin structure into a mainly toroid like structure. Thi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-29 | PXD018843 | Pride
Epididymal sperm Mouse Lc-ms Protamine2 deficient Male Proteome 
ProteomicsPFN4 is required for acrosome biogenesis by regulating autophagy through PI3K/AKT/mTOR pathway
We generated Pfn4 knockout mice and showed that male mice are infertile and acrosome biogenesis is impaired from first phase of Development (Golgi-phase). Autophagy participates in acrosome formation and LC-MS data showed proteins related to autophagy, PI3K/AKT signaling and mTOR are enriched in PFN...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-15 | PXD030394 | Pride
Infertility Autophagy Lc-ms Mouse Profilin 4 
TranscriptomicsTransgenic overexpression of Tcfap2c/AP-2gamma results in liver steatosis
We established a mouse model, in which transcription factor Tcfap2c can be activated in an inducible and reversible manner in somatic tissues, taking advantage of the tetracycline-dependent regulatory system. Induction of the transgene led to robust expression in all tissues (except brain and testis...
ORGANISM(S): Mus musculus 
2011-07-25 | E-GEOD-28692 | biostudies-arrayexpress
GenomicsChIP-seq. analysis of pan-histone 3 acetylation in Romidepsin treated TCam-2
ChIP-seq. analysis of TCam-2 16 h after 10 nanomolar Romidepsin application. DMSO treated cells were used as controls. For ChIP, an antibody against histone H3 pan-acetylation was used. These data are part of the article 'The Histone Deacetylase Inhibitor Romidepsin Efficiently Targets Cisplatin-res...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78262 | biostudies-arrayexpress
TranscriptomicsConversion of murine extraembryonic trophoblast stem cells into induced pluripotent stem cells
Extraembryonic trophoblast stem cells (TSC) can be converted to induced pluripotent stem cells (TSC-iPSCs) by overexpressing Oct4, Sox2, Klf4 and cMyc. TSC lines were derived from mice harboring a doxycycline inducible Oct4 allele and an Oct4-GFP reporter that has been demonstrated to be activated i...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-25872 | biostudies-arrayexpress
TranscriptomicsTranscription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice
Maintenance and maturation of primordial germ cells is controlled by complex genetic and epigenetic cascades, and disturbances in this network lead to either infertility or malignant aberration. Transcription factor Tcfap2c / TFAP2C has been described to be essential for primordial germ cell mainten...
ORGANISM(S): Mus musculus 
2014-01-30 | E-GEOD-45941 | biostudies-arrayexpress
TranscriptomicsDerivation and maintenance of murine trophoblast stem cells under defined conditions
Trophoblast stem (TS) cells are in vitro equivalents to the precursor cells of the placenta. In mice, TS cells can be derived either from polar trophectoderm (TE) of blastocyst outgrowths or from postimplantation extraembryonic ectoderm (ExE), originating from polar TE. Since their first successful ...
ORGANISM(S): Mus musculus 
2014-01-28 | E-GEOD-47719 | biostudies-arrayexpress
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