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TranscriptomicsZebrafish ectonucleoside triphosphate/diphosphohydrolase 5 (entpd5) mutants compared to siblings at 7 dpf
This microarray was performed in attempt to find genes that are related to the presence of entpd5 during embryonic development Embryos were raised in standard E3 medium at 28 degrees Celcius. At 6 dpf mutant were separated from siblings by an in vivo skeletal staining (incubating embryos 5 minutes ...
ORGANISM(S): Danio rerio 
2012-11-29 | E-GEOD-35737 | biostudies-arrayexpress
TranscriptomicsmiR-31 inhibits lymphatic lineage-specific differentiation in vitro and lymphatic vessel development in vivo
The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses and promotes cancer metastasis. MicroRNAs (miRNAs) have recently emerged as key and potent regulators of the genome that control virtually all aspects of cell and organism biology. Surprisingly,...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-16908 | biostudies-arrayexpress
ProteomicsPlasma proteomics of BACE1, 2, and double KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed glycoprotein enrichment and subsequent...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041577 | Pride
Bace2 Glycocapture Beta secretase Plasma 
ProteomicsPlasma proteomics of BACE2 KO mice
The beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. Here, we performed discovery proteomics to identify subst...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD041579 | Pride
Bace2 Beta secretase Plasma Mouse 
ProteomicsPlasma proteomics of mice treated with BACE inhibitors
The Beta-secretase BACE1 is a central drug target for Alzheimer’s disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet, little is known about physiological BACE2 substrates and functions in vivo. To discover potential BAC2 substrates in plasma, mice wer...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD042669 | Pride
Bace Plasma Mus musculus 
ProteomicsMetabolic dependencies in MYCN-driven neuroblastoma
Here we sought metabolic alterations specifically associated with amplified MYCN as nodes to indirectly target the MYCN oncogene. Liquid chromatography-mass spectrometry-based proteomics identified 7 proteins consistently correlated with MYCN in proteomes from 49 neuroblastoma biopsies and 13 cell l...
ORGANISM(S): Homo sapiens (Human) 
2020-12-11 | PXD018300 | Pride
Mycn Cancer cell metabolism De novo serine synthesis pathway One carbon metabolism Therapy resistance Cell death 
UnknownNeuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.
Not available
S-EPMC3584926 | biostudies-literature
GenomicsNINDS-Genome-Wide Genotyping in Parkinson's Disease: First Stage Analysis and Public Release of Data

Epidemiological studies have estimated a cumulative prevalence of PD of greater than 1 per thousand. When prevalence is limited to senior populations, this proportion increases nearly 10-fold. The estimated genetic risk ratio for PD is approximately 1.7 (70% increased risk for PD if a sibling...

phs000089.v3.p2 | EGA
GenomicsWGSeq_HealthyHuman_DATA_SET_xmas_MB_2013_07_10 - samples
HSC73_clone: Bone marrow mononuclear cells from the healthy 73 years old female were thawed and labeled with Alexa-Fluor 488-conjugated anti-CD34 (581, Biolegend), Alexa-Fluor 700-conjugated anti-CD38 (HIT2, eBioscience), a cocktail of APC-conjugated lineage antibodies consisting of anti-CD4 (RPA-T4...
EGAD00001000666 | EGA
TranscriptomicsWB001A: Genome-wide analysis reveals NRP1 as a critical HIF1-E2F7 target gene in the regulation of motor neuron guidance in vivo
In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1α, as we show that expression of E2F7, like HIF1α, is induced in hypoxia, and because of the previously reported ability of E2F7 to interact with HIF1α. Our genome-wide analysis uncovers a transcrip...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-66750 | biostudies-arrayexpress
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