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TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
UnknownThe abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy.
Not available
S-EPMC10087690 | biostudies-literature
UnknownBreastfeeding and the major fermentation metabolite lactate determine occurrence of Peptostreptococcaceae in infant feces.
Not available
S-EPMC10449005 | biostudies-literature
UnknownMeasuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience.
Not available
S-EPMC4188544 | biostudies-literature
TranscriptomicsAffymetrix SNP6.0 array data for EBF1-PDGFRB rearranged acute lymphoblastic leukemia
The EBF1-PDGFRB gene fusion accounts for <1% B-cell precursor acute lymphoblastic leukaemia and occurs within the Philadelphia-like ALL subtype. We performed Affymetrix SNP 6.0 array was undertaken patients who tested positive for EBF1-PDGFRB rearrangement by FISH and/or RT-PCR. We performed Affymet...
ORGANISM(S): Homo sapiens 
2016-04-05 | E-GEOD-77557 | biostudies-arrayexpress
UnknownGenetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Not available
S-EPMC4879695 | biostudies-literature
ProteomicsImpaired stability of tumor cells after targeting of lactate/pyruvate metabolism investigated by shotgun proteomics
Overexpression of heat shock proteins (HSPs), especially the major stress-inducible 72 kDa heat shock protein 70 (Hsp70), in malignant tumor cells is associated with therapeutic resistance. The heightened metabolic demand in tumor cells (Warburg effect) increases lactate dehydrogenase (LDH) activity...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026078 | Pride
Lc-msms Heat shock proteins Lactate/pyruvate metabolism Ldha/b double knockout Membrane hsp70 expression Radiosensitivity 
UnknownEffect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.
Not available
S-EPMC4349346 | biostudies-literature
UnknownMorphological bases of phytoplankton energy management and physiological responses unveiled by 3D subcellular imaging
Not available
ORGANISM(S): Microalgae cell 
S-BSST575 | bioimages
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