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MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
TranscriptomicsMolecular variability of FLT3/ITD mutants and their impact on the differentiation program of 32D cells
FLT3 is the most frequently mutated gene in AML – up to 40% of AML harbor an activating mutation within FLT3 gene. Though AML is a relatively rare disease, such a high mutability rate, as observed with FLT3 gene, is striking. To elucidate the molecular background of this phenomenon, we have establ...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-12766 | biostudies-arrayexpress
UnknownImpact of protein and small molecule interactions on kinase conformations.
Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease-associated kinases using the high sensit...
S-EPMC11293870 | biostudies-literature
ProteomicsTGFβ-signalling and FOXG1 expression hallmark astrocyte lineage diversity in the murine ventral and dorsal forebrain
Heterogeneous astrocyte populations are defined by diversity in cellular environment, progenitor identity or function. Yet, little is known about the extent of the heterogeneity and how this diversity is acquired during development. We used SILAC and quantitative proteomics to characterise primary m...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-02 | PXD005072 | Pride
Astrocytes Neural progenitors Silac Ls-ms 
ProteomicsExtensive folding variability between homologous chromosomes in mammalian cells
Genetic variation and 3D chromatin structure have major roles in gene regulation. Structural differences between genotypically different chromosomes and their effects on gene expression remain ill understood, due to challenges in mapping 3D genome structure with allele-specific resolution. Here, we ...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD048969 | Pride
Lc-msms Genome architecture mapping (gam) Chromatin Polycomb 
TranscriptomicsGDF5 variant with superior healing capacity
Seventy-two female Sprague-Dawley rats underwent a 5 mm critical-sized femoral segmental defect followed by stabilization with a custom-made unilateral external fixator. Following femoral defect generation, absorbable type I bovine collagen sponges were loaded either with 50 ug GDF5wt or 50 ug GDF5N...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-MTAB-2249 | biostudies-arrayexpress
TranscriptomicsGenes affected by manipulation of LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer
The long non coding RNA LIMT was found in our study to inhibit cellular migration in vitro and to inhibit colonization of mammary tumorigenic cells in lungs of mice in vivo. In order to uncover the mechanism enabling these tumor suppressive functions of LIMT the expression of this lncRNA was knocked...
ORGANISM(S): Homo sapiens 
2017-07-27 | E-MTAB-4821 | biostudies-arrayexpress
UnknownPrevention of type 2 diabetes through prediabetes remission without weight loss.
Clinical practice guidelines recommend defined weight loss goals for the prevention of type 2 diabetes (T2D) in those individuals with increased risk, such as prediabetes. However, achieving prediabetes remission, that is, reaching normal glucose regulation according to American Diabetes Association...
S-EPMC12532634 | biostudies-literature
UnknownGenome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.
We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested th...
S-EPMC3059436 | biostudies-literature
UnknownThe Lancet NCDI Poverty Commission: bridging a gap in universal health coverage for the poorest billion.
Not available
S-EPMC7489932 | biostudies-literature
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