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ProteomicsAI-powered Deep Visual Proteomics unmasks critical molecular transitions in pancreatic cancer precursors
Pancreatic ductal adenocarcinoma (PDAC) evolves through precursors, yet the protein programs that govern early progression remain poorly defined. We applied Deep Visual Proteomics - computational pathology, laser microdissection, and mass spectrometry (MS) - to profile normal ducts, acinar-to-ductal...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD072559 | Pride
Deep visual proteomics Laser microdissection Pathology foundation models Mass spectrometry Artificial intelligence Precursor Spatial Tumor Pancreatic ductal adenocarcinoma 
ProteomicsEarly fallopian tube lesions and HGSC spatial proteomics dataset
High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for early-stage cancer detection and development of effective treatment stategies. We perform...
ORGANISM(S): Homo sapiens (Human) 
2026-09-29 | PXD084823 | Pride
Fallopian tube cancer precursors Ovarian cancer Spatial proteomics Hgsc Stic (serous tubal intraepithelial carcinoma) 
ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-22 | MSV000090956 | MassIVE
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
TranscriptomicsRobust Molecular Classification of Ependymal Tumors Across All Anatomic Compartments
Ependymal tumors across age groups have been classified solely by histopathology. It is, however, commonly accepted that this classification has limited clinical utility based on its poor reliability. We aimed at establishing a reliable and reproducible molecular classification using DNA methylation...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-65362 | biostudies-arrayexpress
UnknownLRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
Not available
S-SCDT-10_15252-EMMM_202318014 | biostudies-other
TranscriptomicsIntegrated epigenetic and copy-number profiling identifies three clinically and biologically relevant groups of anaplastic glioma
The outcome of patients with anaplastic gliomas varies considerably depending on histology and single molecular markers such as codeletion of 1p/19q and mutations of the isocitrate dehydrogenase (IDH) gene. Whether a molecularly-based classification of anaplastic gliomas based on large scale genomic...
ORGANISM(S): Homo sapiens 
2014-06-06 | E-GEOD-58218 | biostudies-arrayexpress
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