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ProteomicsProteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
Ubiquitin carboxyl-terminal hydrolase 19 (USP19) is a unique deubiquitinase (DUB), characterized by multiple variants generated by alternative splicing. Several variants bear a C-terminal transmembrane domain that anchors them to the endoplasmic reticulum (ER). Other than regulating protein stabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055064 | Pride
Lysosome Cathepsins. Ubiquitin carboxyl-terminal hydrolase 19  proteomics  unconventional secretion  secretome  legumain 
ProteomicsProteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
Ubiquitin carboxyl-terminal hydrolase 19 (USP19) is a unique deubiquitinase (DUB), characterized by multiple variants generated by alternative splicing. Several variants bear a C-terminal transmembrane domain that anchors them to the endoplasmic reticulum (ER). Other than regulating protein stabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055081 | Pride
Lysosome Cathepsins. Ubiquitin carboxyl-terminal hydrolase 19  proteomics  unconventional secretion  secretome  legumain 
ProteomicsProteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins
Ubiquitin carboxyl-terminal hydrolase 19 (USP19) is a unique deubiquitinase (DUB), characterized by multiple variants generated by alternative splicing. Several variants bear a C-terminal transmembrane domain that anchors them to the endoplasmic reticulum (ER). Other than regulating protein stabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055118 | Pride
Lysosome Cathepsins. Ubiquitin carboxyl-terminal hydrolase 19  proteomics  unconventional secretion  secretome  legumain 
ProteomicsEnhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids.
Cancer remains the leading cause of death globally, with nearly 20 million new cases and 10 million fatalities in 2022. The majority (90%) are solid tumors, which are strongly influenced by the tumor microenvironment (TME)—a complex network of blood vessels, connective tissues, immune cells, and the...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD061082 | Pride
Collagen 3d spheroids Breast cancer Extracellular matrix (ecm) Drug penetration Tumor microenvironment (tme) 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17 - Evaluation of heparin effects on sample preparation PreOmics
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055002 | Pride
Sheddome Adam17 Ectodomain shedding Heparin Disintegrin metalloproteinases Secretome 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17. Evaluation of heparin effects on sample preparation by FASP.
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-23 | PXD054987 | Pride
Sheddome Adam17 Ectodomain shedding Disintegrin metalloproteinases Secretome 
ProteomicsA Vascularized Three-Dimensional Breast Cancer Model: Mimicking the Tumor Microenvironment and Chemoresistance
Tumorigenesis is a complex and dynamic process in which the tumor microenvironment (TME) plays a central role. In solid tumors, the TME contributes to key mechanisms of tumor progression, including metastasis, immune evasion, and resistance to therapies. One major challenge in preclinical cancer res...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-23 | PXD067876 | Pride
Angiogenesis  spheroids  microvascular fragments  tumor microenvironment  3d tumor model 
ProteomicsProteome profiling of cerebrospinal fluid and machine learning reveal biomarkers of two forms of Alzheimer’s disease characterized by increased or not altered levels of tau
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs memory, cognition, behavior, and other cognitive functions. Despite significant advances in understanding its molecular mechanisms, a definitive cure remains elusive. However, some treatments have the potential to slow...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063058 | Pride
Alzherimer’s disease – cerebrospinal fluid – proteomics – machine learning – biomarkers 
ProteomicsiRhom2 regulates HMGB1 secretion to modulate inflammation and hepatocyte senescence in an in vitro model of ischemia/reperfusion injury
Background and Aims: Ischemia/reperfusion injury (IRI), considered one of the most important causes of liver organ rejection in acute and chronic phases, generates an inflammatory environment leading to compromised allograft functionality and rejection. In the last ten years, iRhom2 emerged as an es...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD046469 | Pride
Liver transplant  ischemia/reperfusion  inflammation  irhom2  hmgb1  cellular senescence  secretomics. 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-15 | PXD055223 | Pride
Adam17 Ectodomain shedding Mouse Hepsec Secretome Metalloproteases 
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