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HMGB1 as a rheostat of chromatin topology and RNA homeostasis on the path to senescence [sCLIP]
Only ~4% of the human proteome has been drugged by FDA approved molecules. Consequently, closing this druggability gap is a central focus of mass spectrometry chemoproteomics screening platforms. Despite increasingly widespread adoption, established chemoproteomic platforms fall short of achieving c...
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD040737 | Pride
Only ~4% of the human proteome has been drugged by FDA approved molecules. Consequently, closing this druggability gap is a central focus of mass spectrometry chemoproteomics screening platforms. Despite increasingly widespread adoption, established chemoproteomic platforms fall short of achieving c...
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD040696 | Pride
RNA-binding proteins (RBPs) are central for gene expression by controlling the RNA fate from birth to decay. Various disorders arising from perturbations of RNA-protein interactions document their critical function. However, deciphering their function is complex, limiting the general functional eluc...
ORGANISM(S): Homo sapiens 
2017-03-01 | GSE92996 | GEO
RNA-binding proteins (RBPs) are central for gene expression by controlling the RNA fate from birth to decay. Various disorders arising from perturbations of RNA-protein interactions document their critical function. However, deciphering their function is complex, limiting the general functional eluc...
ORGANISM(S): Homo sapiens 
2017-03-01 | GSE92995 | GEO
Spatial organization and gene expression of mammalian chromosomes are maintained and regulated in conjunction with cell cycle progression. This link is perturbed once cells enter senescence. The highly abundant HMGB1 protein, known to associate with bent and looped DNA, is actively depleted from sen...
ORGANISM(S): Homo sapiens 
2021-06-23 | GSE146047 | GEO
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