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ProteomicsSupplementary Dataset 12 - Alkyne-2PCA clicked to biotin-DADPS-azide enrichment with E coli proteome derived peptide libraries
Alkyne-2PCA clicked to biotin-DADPS-azide enrichment with E coli proteome derived peptide libraries
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2023-02-11 | MSV000091258 | MassIVE
ProteomicsEvaluation and Optimization of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Protein Interactomes
Numerous reagents have been developed to enable chemical proteomic analysis of small molecule-protein interactomes. However, the performance of these reagents has not been systematically evaluated and compared. Herein, we report our efforts to conduct a parallel assessment of two widely-used chemica...
ORGANISM(S): Homo sapiens (Human) 
2019-08-21 | PXD014066 | Pride
Azobenzene Dacomitinib Tmt Cleavable biotin linker Dialkoxydiphenylsilane 
ProteomicsComprehensive evaluation of cleavable bioorthogonal probes for site-specific O-GlcNAc proteomics
O-linked β-N-acetylglucosamine (O-GlcNAc) modification (i.e., O-GlcNAcylation) on proteins is an essential modification in physiology and pathology. Although O-GlcNAcylation is functionally critical, its analysis has never been an easy task. Despite the existence of a number of methods developed in ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-20 | PXD063995 | Pride
Mouse brain O-glcnac Click chemistry Lc-ms/ms 
UnknownAcid cleavable biotin-alkyne improves sensitivity for direct detection of biotin labeled peptides in BONCAT analysis.
Not available
S-EPMC11275937 | biostudies-literature
UnknownAcid Cleavable Biotin-Alkyne Improves Sensitivity for Direct Detection of Biotin Labeled Peptides in Biorthogonal Noncanonical Amino Acid Tagging Analysis.
Not available
S-EPMC12067412 | biostudies-literature
ProteomicsAcid cleavable biotin-alkyne improves sensitivity for direct detection of biotin labeled peptides in BONCAT analysis.
BONCAT (Biorthogonal noncanonical amino acid tagging) is a labeling strategy that covalently adds a biotin-alkyne (BA) to methionine analogs via a click reaction. When methionine analogs are incorporated into a proteome, enrichment of the BA-labeled proteins allows the detection of newly synthesize...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-15 | MSV000095342 | MassIVE
ProteomicsO-GlcNAc sites identification and quantification proteomics analysis of O-GlcNAc chromatin in MCF-7 and MCF-7/ADR cells
We used a metabolic labeling (GalNAz) based O-GlcNAc sites identification and quantification proteomics method to compare the O-GlcNAc chromatin of MCF-7 and MCF-7/ADR cells. The O-GlcNAc chromatin-associated proteins can be metabolically labeled with azides, followed by reaction with a cleavable DA...
ORGANISM(S): Homo Sapiens 
2020-12-01 | PXD022857 |
ProteomicsA solid-phase compatible silane-based cleavable linker enables custom isobaric quantitative chemoproteomics
Only ~4% of the human proteome has been drugged by FDA approved molecules. Consequently, closing this druggability gap is a central focus of mass spectrometry chemoproteomics screening platforms. Despite increasingly widespread adoption, established chemoproteomic platforms fall short of achieving c...
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD040737 | Pride
Cleavable Ms2 Tmt Isobaric Sclip Dadps Lc-msms Solid-phase 
ProteomicsA solid-phase compatible silane-based cleavable linker enables custom isobaric quantitative chemoproteomics
Only ~4% of the human proteome has been drugged by FDA approved molecules. Consequently, closing this druggability gap is a central focus of mass spectrometry chemoproteomics screening platforms. Despite increasingly widespread adoption, established chemoproteomic platforms fall short of achieving c...
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD040696 | Pride
Cleavable Ms2 Tmt Isobaric Sclip Dadps Lc-msms Solid-phase 
UnknownSolid-Phase Compatible Silane-Based Cleavable Linker Enables Custom Isobaric Quantitative Chemoproteomics.
Not available
S-EPMC11895830 | biostudies-literature
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