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ProteomicsEvaluation and Optimization of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Protein Interactomes
Numerous reagents have been developed to enable chemical proteomic analysis of small molecule-protein interactomes. However, the performance of these reagents has not been systematically evaluated and compared. Herein, we report our efforts to conduct a parallel assessment of two widely-used chemica...
ORGANISM(S): Homo sapiens (Human) 
2019-08-21 | PXD014066 | Pride
Azobenzene Dacomitinib Tmt Cleavable biotin linker Dialkoxydiphenylsilane 
UnknownSolid-Phase Compatible Silane-Based Cleavable Linker Enables Custom Isobaric Quantitative Chemoproteomics.
Not available
S-EPMC11895830 | biostudies-literature
UnknownComprehensive Evaluation of Cleavable Bioorthogonal Probes for Site-Specific O-GlcNAc Proteomics.
Not available
S-EPMC12506516 | biostudies-literature
ProteomicsO-GlcNAc sites identification and quantification proteomics analysis of O-GlcNAc chromatin in MCF-7 and MCF-7/ADR cells
We used a metabolic labeling (GalNAz) based O-GlcNAc sites identification and quantification proteomics method to compare the O-GlcNAc chromatin of MCF-7 and MCF-7/ADR cells. The O-GlcNAc chromatin-associated proteins can be metabolically labeled with azides, followed by reaction with a cleavable DA...
ORGANISM(S): Homo Sapiens 
2020-12-01 | PXD022857 |
ProteomicsComprehensive evaluation of cleavable bioorthogonal probes for site-specific O-GlcNAc proteomics
O-linked β-N-acetylglucosamine (O-GlcNAc) modification (i.e., O-GlcNAcylation) on proteins is an essential modification in physiology and pathology. Although O-GlcNAcylation is functionally critical, its analysis has never been an easy task. Despite the existence of a number of methods developed in ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-20 | PXD063995 | Pride
Mouse brain O-glcnac Click chemistry Lc-ms/ms 
ProteomicsBenchmarking cleavable biotin tags for site-centric chemoproteomics
the performance of five common cleavable biotin linkers are assessed parallelly by using commercially available thiol-reactive probe IPM (2-iodo-N-(prop-2-yn-1-yl)acetamide) in profiling cysteinome
ORGANISM(S): Homo Sapiens 
2022-01-16 | PXD031019 |
ProteomicsIdentification of a Potent Tau-Aggregate Clearing Compound Using Chemoproteomic-Integrated Phenotypic Screening (Enrichment)
Tauopathies are characterized by the formation of tau protein-based neurofibrillary tangles which impede neuronal function and contribute to the pathology of highly prevalent neurodegenerative disorders such as Alzheimer’s and Pick’s diseases. Despite the impact of these diseases, the underlying bio...
ORGANISM(S): Homo sapiens (Human) 
2025-09-05 | PXD056703 | Pride
Fragment Tauopathy Screening Chemoproteomics Photoactivation 
ProteomicsPMSF/vanadate oxidation effect on Human PANC-1 cells
Cysteines play critical roles in redox regulation and can be covalently engaged by electrophiles to inform on cysteine function and targetability. Here, we compare cysteine engagement by a PMSF/orthovanadate-derived oxidant with that of pervanadate, another vanadium-based oxidant.
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD076162 | Pride
ProteomicsA General Approach for Activity-based Protein Profiling of Oxidoreductases with Redox-differentiated Diarylhalonium Warheads
Activity-based protein profiling (ABPP) is a unique proteomic tool for measuring the activity of enzymes in their cellular context, which has been well established for enzyme classes exhibiting a characteristic nucleophilic residue (e.g. hydrolases). In contrast, the enzyme class of oxidoreductases ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD043873 | Pride
Oxidoreductase probe Mouse liver; Activity-based protein profiling 
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